Shang Bowen, Guan Guijian
Institute of Molecular Plus, Tianjin University, Tianjin 300072, China.
Materials (Basel). 2025 Jun 4;18(11):2627. doi: 10.3390/ma18112627.
The integration of chirality into nanomaterials holds significant potential for improving molecular recognition and biomedical technologies. In this work, we fabricated novel chiral horned gold nanostructures (HNS) by controlling the concentration of chiral ligands L-/D-cysteine (Cys). The unique three-dimensional morphology with horns-rotational arrangement enables synergistic optimization of chiral optical responses and surface-enhanced Raman scattering (SERS) performance. The proposed chiral HNSs can be used to recognize amino acid enantiomers, in which homochiral amino acid has distinct affinities to the chiral HNSs of homogeneous handedness. The 4-mercaptobenzoic acid (4-MPBA)-modified D-HNS demonstrates significantly enhanced targeting affinity for D-amino acids in the () cell wall, enabling successful amplification of SERS signals and advancing bacterial detection methodologies. By demonstrating the rotation-selective interaction between chiral HNSs and circularly polarized light (CPL), D-HNS exhibits excellent photothermal conversion efficiency under right-handed circularly polarized light (RCP) irradiation. This enables the synergistic combination of targeted physical disruption and photothermal sterilization, which leads to efficient eradication of . The D-HNS hydrogel composite system further expands the practical application of photothermal sterilization. Altogether, chiral HNSs have achieved SERS detection of bacteria and efficient polarization photothermal sterilization, which helps further develop applications based on chiral nanomaterials.
将手性整合到纳米材料中在改善分子识别和生物医学技术方面具有巨大潜力。在这项工作中，我们通过控制手性配体L-/D-半胱氨酸（Cys）的浓度制备了新型手性角状金纳米结构（HNS）。具有角旋转排列的独特三维形态能够对手性光学响应和表面增强拉曼散射（SERS）性能进行协同优化。所提出的手性HNS可用于识别氨基酸对映体，其中同手性氨基酸对相同手性的手性HNS具有不同的亲和力。4-巯基苯甲酸（4-MPBA）修饰的D-HNS对（）细胞壁中的D-氨基酸表现出显著增强的靶向亲和力，能够成功放大SERS信号并推进细菌检测方法。通过证明手性HNS与圆偏振光（CPL）之间的旋转选择性相互作用，D-HNS在右旋圆偏振光（RCP）照射下表现出优异的光热转换效率。这使得靶向物理破坏和光热杀菌能够协同结合，从而有效根除。D-HNS水凝胶复合系统进一步扩展了光热杀菌的实际应用。总之，手性HNS实现了细菌的SERS检测和高效偏振光热杀菌，这有助于进一步开发基于手性纳米材料的应用。
