Suppr超能文献

含药美洛昔康微丸可降低去角奶牛犊牛的一些疼痛指标。

Medicated Meloxicam Pellets Reduce Some Indicators of Pain in Disbudded Dairy Calves.

作者信息

Scerri Tiarna, Lomax Sabrina, Thomson Peter, Kimble Benjamin, White Peter, Govendir Merran, Clark Cameron, Van der Saag Dominique

机构信息

School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.

Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW 2006, Australia.

出版信息

Animals (Basel). 2025 Jun 3;15(11):1641. doi: 10.3390/ani15111641.

Abstract

Disbudding is a husbandry practice that causes pain and discomfort to calves. As a prominent welfare concern, it is now standard practice for calves to be given analgesic treatment such as a nonsteroidal anti-inflammatory drug (NSAID) injection. Meloxicam is a commonly used NSAID as it provides pain relief for up to 44 h following disbudding. However, since symptoms can persist for up to two weeks, it was hypothesised that more prolonged analgesic treatment would promote better welfare outcomes than the conventional injection. This study tested a novel treatment whereby disbudded calves were fed grain-based pellets medicated with meloxicam over a 7-day period. Lower levels of horn site inflammation were observed for the pellet treatment across the 7-day feeding period in comparison to the conventional injection. The pellet treatment calves also exhibited less pain-specific and more positive social-specific behaviours during and beyond the feeding period. Together, these results suggest that lower levels of inflammation enacted by prolonged meloxicam administration have an active role in reducing pain and maintaining the affectivity of disbudded calves. With the goal of establishing sustained disbudding treatment as a new industry standard, future research will focus on larger-scale results reproducibility and maximising treatment practicality.

摘要

去角是一种给小牛带来疼痛和不适的饲养操作。作为一个突出的福利问题,现在的标准做法是给小牛进行镇痛治疗,如注射非甾体抗炎药(NSAID)。美洛昔康是一种常用的NSAID,因为它在去角后能提供长达44小时的疼痛缓解。然而,由于症状可能持续长达两周,因此有人推测,比传统注射更长期的镇痛治疗将促进更好的福利结果。本研究测试了一种新型治疗方法,即给去角小牛在7天时间内喂食含有美洛昔康的谷物颗粒。与传统注射相比,在7天的喂食期内,颗粒治疗组的角部位炎症水平较低。颗粒治疗组的小牛在喂食期间及之后也表现出较少的疼痛特异性行为和较多的积极社交特异性行为。总之,这些结果表明,长期服用美洛昔康所产生的较低炎症水平在减轻疼痛和维持去角小牛的情感方面具有积极作用。为了将持续去角治疗确立为新的行业标准,未来的研究将集中在更大规模的结果可重复性以及最大化治疗实用性上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dc6/12153791/0cd2954cf3c2/animals-15-01641-g0A1.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验