来自花朵的生物活性化合物：对乳腺癌细胞具有强大的抗菌和抗增殖作用。

Bioactive Compounds from Flowers: Potent Antibacterial and Antiproliferative Effects in Breast Cancer Cells.

作者信息

Raksat Achara, Yee Daniel, Gi Young Jin, Wongwiwatthananukit Supakit, Chang Leng Kar, Kaawaloa Kumu Piilani, Wall Marisa M, Lee Jangsoon, Chang Leng Chee

机构信息

Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.

Preclinical Core, Cancer Biology Program, University of Hawai'i Cancer Center, Honolulu, HI 96813, USA.

出版信息

Molecules. 2025 May 22;30(11):2274. doi: 10.3390/molecules30112274.

DOI:10.3390/molecules30112274

PMID:40509161

Abstract

(Sapindaceae), a Hawaiian local medicinal plant, has been traditionally used to treat rashes and skin diseases. The study aimed to discover and characterize bioactive compounds from flowers extract with antimicrobial and antitumor properties. Thirteen compounds were isolated from the methanol extract of flowers, and their structures were characterized using spectroscopy data, comparing their NMR spectroscopic profiles with previously reported data. Subsequent antibacterial assays revealed that one particular compound, , exhibited significant antimicrobial activity against Gram-positive bacteria. Notably, it demonstrated a minimum inhibitory concentration (MIC) of 2 μg/mL, indicating its potent antibacterial potential. In addition to antimicrobial properties, the isolated compounds demonstrated dose-dependent antiproliferative effects in breast cancer cell lines. Notably, inflammatory breast cancer (IBC) cell lines, a highly aggressive subtype, were more sensitive to compound , with IC values of 4.22 μM (BCX-010), 6.74 μM (SUM190), and 7.73 (SUM149), compared to non-IBC cell line. These findings highlight the dual antibacterial and anticancer potential of compounds from , emphasizing their promise as candidates for therapeutic development.

摘要

无患子科（Sapindaceae）的一种夏威夷本土药用植物，传统上用于治疗皮疹和皮肤病。该研究旨在从具有抗菌和抗肿瘤特性的花朵提取物中发现并表征生物活性化合物。从花朵的甲醇提取物中分离出13种化合物，并利用光谱数据对其结构进行表征，将它们的核磁共振光谱图谱与先前报道的数据进行比较。随后的抗菌试验表明，一种特定的化合物对革兰氏阳性菌表现出显著的抗菌活性。值得注意的是，它的最低抑菌浓度（MIC）为2μg/mL，表明其具有强大的抗菌潜力。除了抗菌特性外，分离出的化合物在乳腺癌细胞系中表现出剂量依赖性的抗增殖作用。值得注意的是，炎性乳腺癌（IBC）细胞系，一种高度侵袭性的亚型，对化合物更敏感，与非IBC细胞系相比，其IC值分别为4.22μM（BCX-010）、6.74μM（SUM190）和7.73（SUM149）。这些发现突出了该植物化合物的双重抗菌和抗癌潜力，强调了它们作为治疗开发候选物的前景。