Dong Hezeng, Liu Zhaozheng, Zhang Jinling, Han Ye, Zhang Jing, Xi Yazhi, Chang Liping, Deng Yue
College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China.
Heart Disease Center, Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China.
Front Endocrinol (Lausanne). 2025 May 29;16:1474467. doi: 10.3389/fendo.2025.1474467. eCollection 2025.
The ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) serves as a predictive indicator for metabolic syndrome and cardiovascular diseases. Simultaneously, nocturnal hypertension significantly increases the risk of target organ damage and cardiovascular events. However, the relationship between the TG/HDL-C ratio and nocturnal hypertension remains unclear. Therefore, the present study aimed to determine the efficacy of the TG/HDL-C ratio in predicting the occurrence of nocturnal hypertension and reducing related adverse events.
Our rigorous cross-sectional study, which included 749 participants who underwent 24-hour ambulatory blood pressure monitoring at the Cardiology Center of Changchun University of Chinese Medicine Affiliated Hospital, allowed us to determine the association between the TG/HDL-C ratio and nocturnal hypertension. We employed both univariate and multivariate logistic regression analyses to ensure the robustness of our findings. Logistic regression modeling was used to assess the independent predictive ability of TG/HDL-C for nocturnal hypertension while adjusting for confounders such as sex, age, BMI, and smoking status. Model performance was assessed by subject work characteristics (ROC) curves and area under the curve (AUC).
Among the 749 participants included in this study, 566 were identified with nocturnal hypertension. Univariate logistic regression analysis demonstrated that the TG/HDL-C ratio was positively correlated with the occurrence of nocturnal hypertension, with the risk of nocturnal hypertension increasing by 24% (OR 1.24(1.06-1.45), P=0.006) for every 1-unit increase in the TG/HDL-C ratio. After adjusting for past medical history, medication, and other relevant examinations, a multivariate analysis revealed a significant correlation between the TG/HDL-C ratio and nocturnal hypertension. Logistic regression analysis demonstrated that TG/HDL-C was positively associated with nocturnal hypertension (regression coefficient = 0.115, P < 0.05). After adjusting for sex, age, BMI, and smoking status, TG/HDL-C remained a predictor of nocturnal hypertension.
Our study underscores the significant association between an elevated TG/HDL-C ratio and the occurrence of nocturnal hypertension. This finding has the potential to draw the attention of patients and physicians to lipid levels, particularly among males, individuals over 45 years old, those with a BMI greater than 24, smokers, and those with a history of hypertension. An independent positive association between TG/HDL-C and nocturnal hypertension was also determined using logistic regression modeling. The findings suggests that it may have potential application in the early screening of nocturnal hypertension. However, the predictive ability is limited, and further studies are necessary to incorporate larger sample sizes and longitudinal designs. These additional studies would validate the predictive role of TG/HDL-C and explore its biological mechanisms.
甘油三酯与高密度脂蛋白胆固醇的比值（TG/HDL-C）是代谢综合征和心血管疾病的预测指标。同时，夜间高血压会显著增加靶器官损害和心血管事件的风险。然而，TG/HDL-C比值与夜间高血压之间的关系仍不清楚。因此，本研究旨在确定TG/HDL-C比值在预测夜间高血压发生及减少相关不良事件方面的效果。
我们进行了一项严谨的横断面研究，纳入了长春中医药大学附属医院心脏病中心749名接受24小时动态血压监测的参与者，以确定TG/HDL-C比值与夜间高血压之间的关联。我们采用单因素和多因素逻辑回归分析以确保研究结果的稳健性。逻辑回归模型用于评估TG/HDL-C对夜间高血压的独立预测能力，同时对性别、年龄、体重指数（BMI）和吸烟状况等混杂因素进行校正。通过受试者工作特征（ROC）曲线和曲线下面积（AUC）评估模型性能。
在本研究纳入的749名参与者中，566人被诊断为夜间高血压。单因素逻辑回归分析表明，TG/HDL-C比值与夜间高血压的发生呈正相关，TG/HDL-C比值每增加1个单位，夜间高血压风险增加24%（比值比[OR]1.24[1.06 - 1.45]，P = 0.006）。在对既往病史、用药情况及其他相关检查进行校正后，多因素分析显示TG/HDL-C比值与夜间高血压之间存在显著相关性。逻辑回归分析表明，TG/HDL-C与夜间高血压呈正相关（回归系数 = 0.115，P < 0.05）。在对性别、年龄、BMI和吸烟状况进行校正后，TG/HDL-C仍然是夜间高血压的预测指标。
我们的研究强调了TG/HDL-C比值升高与夜间高血压发生之间的显著关联。这一发现可能会引起患者和医生对血脂水平的关注，尤其是男性、45岁以上人群、BMI大于24者、吸烟者以及有高血压病史者。通过逻辑回归模型还确定了TG/HDL-C与夜间高血压之间存在独立的正相关。研究结果表明，它可能在夜间高血压的早期筛查中具有潜在应用价值。然而，其预测能力有限，需要进一步开展更大样本量和纵向设计的研究。这些额外的研究将验证TG/HDL-C的预测作用并探索其生物学机制。
