中国中老年人甘油三酯/高密度脂蛋白胆固醇与高血压的关联：基于中国健康与养老追踪调查（CHARLS）的发现

Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS.

作者信息

Wang Lerui, Chen Xiao, Lai Weicheng, Liu Junxi, Zhou Boda

机构信息

Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.

School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.

出版信息

BMC Cardiovasc Disord. 2025 Apr 4;25(1):254. doi: 10.1186/s12872-025-04712-w.

DOI:10.1186/s12872-025-04712-w

PMID:40186166

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11969809/

Abstract

BACKGROUND

The triacylglycerol to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been recognized as one of the risk factors for cardiovascular diseases, insulin resistance and metabolic syndrome. We aimed to investigate the relationship between TG/HDL-C and hypertension in a Chinese middle-aged and elderly population.

METHODS

We used data from the CHARLS database 2011-2018 to explore the relationship between TG/HDL-C and hypertension through cross-sectional and longitudinal studies. Hypertension was identified by self-report or taking anti-hypertensive medications. Participants aged below 45, or with missing data on TG/HDL-C or hypertension record, or taking lipid-lowering medication were excluded. Participants were divided into three or two groups based on triplets TG/HDL-C and median TG/HDL-C in cross-sectional and longitudinal analysis. Multivariate logistic regression analysis, subgroup analysis, and restricted cubic splines were used in statistics.

RESULTS

In the cross-sectional analysis, a total of 12,824 participants were included, after adjusting for potential confounders, there was a significant association between higher TG/HDL-C and increased prevalence of hypertension (OR = 1.86, 95% CI: 1.65-2.09, p < 0.001), systolic blood pressure (SBP) above 140 mmHg (OR = 1.37, 95% CI: 1.25-1.50, p < 0.0001), diastolic blood pressure (DBP) above 90 mmHg (OR = 1.47, 95% CI: 1.29-1.67, p < 0.0001), and pulse pressure (PP) above 60 mmHg (OR = 1.17, 95% CI: 1.07-1.29, p < 0.0011). The longitudinal analysis included 7909 participants, there was a significant association between higher TG/HDL-C and increased incidence of hypertension (OR = 1.51, 95% CI: 1.32-1.73,p < 0.001). Restricted cubic splines show nonlinear relationship between TG/HDL-C and hypertension.

CONCLUSION

These results demonstrated significant positive association between TG/HDL-C and the prevalence & incidence of hypertension, in a nationwide representative middle-aged and elderly population in China.

摘要

背景

甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）已被认为是心血管疾病、胰岛素抵抗和代谢综合征的危险因素之一。我们旨在研究中国中老年人群中TG/HDL-C与高血压之间的关系。

方法

我们使用2011 - 2018年中国健康与养老追踪调查（CHARLS）数据库的数据，通过横断面研究和纵向研究来探讨TG/HDL-C与高血压之间的关系。高血压通过自我报告或服用抗高血压药物来确定。年龄在45岁以下、TG/HDL-C或高血压记录数据缺失、或正在服用降脂药物的参与者被排除。在横断面分析和纵向分析中，根据三分位数TG/HDL-C和中位数TG/HDL-C将参与者分为三组或两组。采用多变量逻辑回归分析、亚组分析和限制性立方样条进行统计学分析。

结果

横断面分析共纳入12824名参与者，在调整潜在混杂因素后，较高的TG/HDL-C与高血压患病率增加（OR = 1.86，95%CI：1.65 - 2.09，p < 0.001）、收缩压（SBP）高于140 mmHg（OR = 1.37，95%CI：1.25 - 1.50，p < 0.0001）、舒张压（DBP）高于90 mmHg（OR = 1.47，95%CI：1.29 - 1.67，p < 0.0001）以及脉压（PP）高于60 mmHg（OR = 1.17，95%CI：1.07 - 1.29，p < 0.0011）之间存在显著关联。纵向分析纳入7909名参与者，较高的TG/HDL-C与高血压发病率增加（OR = 1.51，95%CI：1.32 - 1.73，p < 0.001）之间存在显著关联。限制性立方样条显示TG/HDL-C与高血压之间存在非线性关系。