Lamm Thomas Tandrup, Mehlsen Mimi Yung, Carstensen Tina Birgitte Wisbech, Wellnitz Kaare Bro, Ørnbøl Eva, Dantoft Thomas Meinertz, Fink Per, Petersen Marie Weinreich, Frostholm Lisbeth
Research Clinic for Functional Disorders, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Clin Psychol Eur. 2025 May 28;7(2):e14441. doi: 10.32872/cpe.14441. eCollection 2025 May.
Adverse life events and neuroticism have been shown to be associated with health anxiety (HA), but their interaction has not been studied. This study aimed to examine the separate associations as well as the possible interaction effect of neuroticism and adverse life events with HA.
Cross-sectional self-report data originated from a representative Danish population cohort (DanFunD) ( = 7,493, 18-72 years, 53% females). Primary measures were HA (Whiteley Index 6 revised), neuroticism (NEO personality Inventory Revised short form), and adverse life events (Cumulative Lifetime Adversity Measure, CLAM). The CLAM was split into illness/death related life events (IDE) and other adverse life events (OAE) to test the specificity of IDEs.
Adjusted ordinal logistic regression models showed positive associations with HA for IDEs ( = 1.05, CI [1.03, 1.08]), OAEs ( = 1.05, CI [1.03, 1.07]) and neuroticism ( = 1.08, CI [1.07, 1.09]). A Wald's test revealed no difference in association with HA for IDEs and OAEs ( = .82). Adjusted models showed an interaction effect for neuroticismIDEs ( = 1.002, CI [1.000, 1.004]), but not for neuroticismOAEs ( = 0.999, CI [0.996, 1.002]).
Associations with HA were found for both adverse life events and neuroticism. Size of association did not differ for IDEs and OAEs. Only IDEs interacted with neuroticism.
不良生活事件和神经质已被证明与健康焦虑（HA）相关，但它们之间的相互作用尚未得到研究。本研究旨在探讨神经质和不良生活事件与HA的单独关联以及可能的相互作用效应。
横断面自我报告数据来自具有代表性的丹麦人群队列（DanFunD）（n = 7493，年龄18 - 72岁，53%为女性）。主要测量指标为HA（修订版怀特利指数6）、神经质（修订版NEO人格量表简式）和不良生活事件（累积终身逆境量表，CLAM）。CLAM被分为与疾病/死亡相关的生活事件（IDE）和其他不良生活事件（OAE），以检验IDE的特异性。
调整后的有序逻辑回归模型显示，IDE（β = 1.05，CI [1.03, 1.08]）、OAE（β = 1.05，CI [1.03, 1.07]）和神经质（β = 1.08，CI [1.07, 1.09]）与HA呈正相关。Wald检验显示，IDE和OAE与HA的关联无差异（p = 0.82）。调整后的模型显示神经质IDE存在相互作用效应（β = 1.002，CI [1.000, 1.004]），但神经质OAE不存在相互作用效应（β = 0.999，CI [0.996, 1.002]）。
不良生活事件和神经质均与HA相关。IDE和OAE的关联大小无差异。只有IDE与神经质存在相互作用。
