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针对创伤后应激障碍患者的高强度住院治疗方案结合叙事暴露疗法的可行性及初步疗效

Feasibility and preliminary effectiveness of a highly intensive inpatient treatment programme with Narrative Exposure Therapy for patients with posttraumatic stress disorder.

作者信息

Strijk Patricia J M, Nijdam Mirjam J, Klaassens Ellen R, Bedawi Viyan, de la Rie Simone, Jongedijk Ruud A

机构信息

ARQ Centrum'45, partner in ARQ National Psychotrauma Centre, Oegstgeest, Netherlands.

Department of Psychiatry, Amsterdam University Medical Centers Location University of Amsterdam, Amsterdam Public Health, Amsterdam, Netherlands.

出版信息

Front Psychol. 2025 May 29;16:1516144. doi: 10.3389/fpsyg.2025.1516144. eCollection 2025.

Abstract

INTRODUCTION

Current guidelines recommend trauma-focused therapies for the treatment of post-traumatic stress disorder (PTSD). Unfortunately, the percentage of non-response and dropout with these forms of therapy has proven to be substantial. Trauma-focused therapies offered in a highly intensive format have been found to lead to higher adherence and faster symptom reduction, but no studies so far have investigated Narrative Exposure Therapy (NET) in an intensive programme. The aim of this study was to investigate the feasibility and preliminary effects of a 10-day highly intensive inpatient treatment programme consisting of Narrative Exposure Therapy (NET), Art Therapy (AT) and trauma sensitive yoga (TSY) for patients with severe, chronic PTSD.

METHODS

A non-controlled pilot study was conducted in which 28 individuals diagnosed with PTSD received this highly intensive treatment programme. Outcome measures were administered at baseline, post-treatment and at four-month follow-up. Changes in clinician-rated and self-reported PTSD were explored, as well as changes in depressive symptoms and general psychopathology. Outcome measures were the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), PTSD Check List for DSM-5 (PCL-5), Beck Depression Inventory (BDI-II), and Brief Symptom Inventory (BSI).

RESULTS

From baseline to four-month follow-up, clinician-rated and self-reported PTSD symptom severity significantly decreased with a large effect size (Cohen's 0.80 and 0.84, respectively). Depressive symptom severity showed a medium-sized decrease at post-treatment, which was enhanced at four-month follow-up representing a large effect (Cohen's 0.78). The drop-out rate was 18%.

CONCLUSION

The findings of this study show that applying NET in a highly intensive form is feasible and significant improvements in PTSD and depressive symptoms were demonstrated in patients who had all received previous treatment for their condition. Future research into this promising approach is encouraged, as well as investigating which patients benefit most from highly intensive programs with NET.

摘要

引言

当前指南推荐采用以创伤为重点的疗法来治疗创伤后应激障碍(PTSD)。不幸的是,事实证明这些疗法的无反应率和退出率相当高。已发现以高度密集形式提供的以创伤为重点的疗法能带来更高的依从性和更快的症状减轻,但迄今为止尚无研究在密集项目中调查叙事暴露疗法(NET)。本研究的目的是调查一项为期10天的高度密集住院治疗项目对重度慢性PTSD患者的可行性和初步效果,该项目包括叙事暴露疗法(NET)、艺术疗法(AT)和创伤敏感瑜伽(TSY)。

方法

进行了一项非对照的试点研究,28名被诊断为PTSD的个体接受了这个高度密集的治疗项目。在基线、治疗后和四个月随访时进行结果测量。探讨了临床医生评定和自我报告的PTSD变化,以及抑郁症状和一般精神病理学的变化。结果测量指标包括《精神疾病诊断与统计手册》第5版临床医生管理的PTSD量表(CAPS-5)、《精神疾病诊断与统计手册》第5版PTSD检查表(PCL-5)、贝克抑郁量表(BDI-II)和简明症状量表(BSI)。

结果

从基线到四个月随访,临床医生评定和自我报告的PTSD症状严重程度显著降低,效应量较大(科恩d值分别为0.80和0.84)。抑郁症状严重程度在治疗后显示出中等程度的下降,在四个月随访时有所增强,代表着较大的效应(科恩d值为0.78)。退出率为18%。

结论

本研究结果表明,以高度密集形式应用NET是可行的,并且在所有之前都针对其病情接受过治疗的患者中,PTSD和抑郁症状有显著改善。鼓励对这种有前景的方法进行未来研究,以及调查哪些患者从NET高度密集项目中获益最大。

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