Vaishnavi Venugopal, Shetty Ashish Kumar, Balakrishna Rithesh Kenchapal
Department of Oral and Maxillofacial Surgery, AJ Institute of Dental Sciences, Mangalore, Karnataka, India.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S498-S500. doi: 10.4103/jpbs.jpbs_1832_24. Epub 2025 Apr 9.
Temporomandibular joint (TMJ) internal derangement (ID) is a prevalent disorder causing significant pain and dysfunction. Initial treatment typically involves conservative methods, with ozone gas injection emerging as a potential therapy. This study evaluates the efficacy of intra-articular ozone gas injection in treating TMJ ID.
Twenty patients diagnosed with Wilkes stage II and III TMJ ID received ozone gas injections into the periarticular tissues and superior joint space. Maximal interincisal mouth opening and TMJ pain scores were assessed at 28 and 42 days post treatment.
There were significant improvements in maximal mouth opening and reductions in TMJ pain scores from baseline to the 42 day post injection.
Intra-articular ozone gas injection offers a minimally invasive, cost-effective treatment for TMJ ID, showing substantial benefits before considering more invasive procedures.
颞下颌关节（TMJ）内紊乱（ID）是一种常见疾病，会导致严重疼痛和功能障碍。初始治疗通常采用保守方法，臭氧气体注射已成为一种潜在的治疗手段。本研究评估关节内臭氧气体注射治疗TMJ ID的疗效。
20例被诊断为威尔克斯II期和III期TMJ ID的患者接受了关节周围组织和关节上间隙的臭氧气体注射。在治疗后28天和42天评估最大切牙间开口度和TMJ疼痛评分。
从基线到注射后42天，最大开口度有显著改善，TMJ疼痛评分降低。
关节内臭氧气体注射为TMJ ID提供了一种微创、经济有效的治疗方法，在考虑更具侵入性的手术之前显示出显著益处。
