Qadiri Syed Yasir, Hossain Malik Mahmud Iqbal, Irum Bushra, Almobti Mohammed Naseer, Magbool Majid Ahmad Abdullah, Al Hutaylah Mohammed Hussain Mahdi
Department of Restorative Dentistry, College of Dentistry, Najran University, Najran, Saudi Arabia.
General Dentist, Najran University, Saudi Arabia.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S495-S497. doi: 10.4103/jpbs.jpbs_1934_24. Epub 2025 Jan 14.
This study evaluated the effectiveness of nano bioactive glass 45S5 in promoting enamel remineralization and inhibiting demineralization, comparing it to traditional fluoride varnish and CPP-ACP treatments.
Forty-five freshly extracted human permanent premolar teeth were sectioned and exposed to a demineralization solution for 48 hours. The teeth were then treated with fluoride varnish (Group I), CPP-ACP paste (Group II), or nano bioactive glass 45S5 paste (Group III) for 10 days. Vickers microhardness was measured at three time points: baseline, postdemineralization, and postremineralization. Data were analyzed using one-way ANOVA, followed by tests for pairwise comparisons.
Significant differences in enamel hardness were observed across all treatment groups at baseline ( < 0.001). After demineralization, Group III (bioactive glass) exhibited the highest postdemineralization hardness ( = 0.050). Post remineralization, Group III demonstrated the highest hardness ( < 0.05).
Bioactive Glass 45S5 showed superior remineralization and demineralization inhibition compared to traditional fluoride varnish and CPP-ACP treatments.
本研究评估了纳米生物活性玻璃45S5在促进牙釉质再矿化和抑制脱矿方面的有效性，并将其与传统氟化物漆和酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）治疗方法进行比较。
将45颗新鲜拔除的人类恒牙前磨牙进行切片，并置于脱矿溶液中48小时。然后，分别用氟化物漆（第一组）、CPP-ACP糊剂（第二组）或纳米生物活性玻璃45S5糊剂（第三组）对牙齿进行处理，为期10天。在三个时间点测量维氏显微硬度：基线、脱矿后和再矿化后。使用单因素方差分析对数据进行分析，随后进行两两比较检验。
在基线时，所有治疗组的牙釉质硬度均存在显著差异（<0.001）。脱矿后，第三组（生物活性玻璃）的脱矿后硬度最高（=0.050）。再矿化后，第三组的硬度最高（<0.05）。
与传统氟化物漆和CPP-ACP治疗方法相比，生物活性玻璃45S5表现出更优异的再矿化和脱矿抑制效果。
