Mareddy Ajay Reddy, Reddy Venugopal N, Done Vasanthi, Rehaman Tarannum, Gadekar Trisha, Raj Monica
Department of Pedodontics, Mamata Dental College, Khammam, Telangana, India.
Int J Clin Pediatr Dent. 2025 Apr;18(4):425-430. doi: 10.5005/jp-journals-10005-3032. Epub 2025 May 19.
To compare and evaluate the effects of bioactive glass (BAG), nano hydroxyapatite (nHAp), and casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF)-based slurry on surface microhardness (SMH) of demineralized enamel.
Thirty-eight extracted deciduous teeth were disinfected in 5.25% sodium hypochlorite solution for 1 hour and stored in 1% thymol prior to specimen preparation. Each tooth was decoronated at the level of the cemento-enamel junction (CEJ), and the crown was sectioned mesiodistally into two halves using a diamond disc. The slurry was prepared by suspending the respective remineralizing agent. The solutions were thoroughly stirred using a magnetic stirrer for 1 minute at room temperature before starting the potential of hydrogen (pH)-cycling. The pH values of all solutions were monitored with a pH-sensitive electrode. After completion of all cycles, microhardness and surface evaluation were done using the Vickers hardness test and sent for scanning electron microscopy (SEM) analysis.
Data obtained were compiled, tabulated, and subjected to statistical analysis using IBM SPSS software version 23. ANOVA test and analysis-Bonferroni test-were used to assess SMH, with ≤0.05 considered statistically significant. Vickers hardness values were analyzed using the ANOVA test. Group I (65.4 ± 3.49) showed the highest hardness value, followed by group IV (58.2 ± 5.02), group III (55.8 ± 10.8), the least among group V (54.2 ± 7.44), and group II (54.1 ± 6.37). The mean hardness values of group I showed a significant difference with all groups except group IV ( = 0.072).
nHA had better potential to remineralize enamel. BAG, nHA, and CPP-ACPF enhanced the SMH values, thus can be considered effective for remineralization.
(1) Nano hydroxyapatite promotes remineralization of enamel and would be advantageous in the treatment of enamel erosion. (2) Bioactive glass, nHAp, and CPP-ACPF improve the SMH values, thus can be considered effective for remineralization.
Mareddy AR, Reddy VN, Done V, . Comparative Evaluation of Three Remineralization Agents-Bioactive Glass, Nanohydroxyapatite and Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride-based Slurry on Enamel Erosion of Primary Teeth: An Study. Int J Clin Pediatr Dent 2025;18(4):425-430.
比较并评估生物活性玻璃（BAG）、纳米羟基磷灰石（nHAp）以及酪蛋白磷酸肽 - 无定形磷酸钙氟化物（CPP - ACPF）基糊剂对脱矿釉质表面显微硬度（SMH）的影响。
38颗拔除的乳牙在5.25%次氯酸钠溶液中消毒1小时，并在制备标本前保存在1%百里酚中。每颗牙齿在牙骨质 - 釉质界（CEJ）水平去冠，然后使用金刚石盘将牙冠近远中向切成两半。通过悬浮相应的再矿化剂制备糊剂。在开始进行氢电极电势（pH）循环之前，使用磁力搅拌器在室温下将溶液充分搅拌1分钟。所有溶液的pH值用pH敏感电极监测。在所有循环完成后，使用维氏硬度测试进行显微硬度和表面评估，并送去进行扫描电子显微镜（SEM）分析。
所获得的数据进行整理、制表，并使用IBM SPSS软件版本23进行统计分析。采用方差分析（ANOVA）测试和分析 - 邦费罗尼（Bonferroni）测试来评估表面显微硬度，以≤0.05为具有统计学意义。使用方差分析测试分析维氏硬度值。第一组（65.4±3.49）显示出最高的硬度值，其次是第四组（58.2±5.02）、第三组（55.8±十.8），第五组（54.2±7.44）中最低，第二组（54.1±6.37）。第一组的平均硬度值与除第四组外的所有组均有显著差异（P = 0.072）。
nHA具有更好的釉质再矿化潜力。BAG、nHA和CPP - ACPF提高了表面显微硬度值，因此可被认为对再矿化有效。
（1）纳米羟基磷灰石促进釉质再矿化，在治疗釉质侵蚀方面具有优势。（2）生物活性玻璃、nHAp和CPP - ACPF提高了表面显微硬度值，因此可被认为对再矿化有效。
Mareddy AR，Reddy VN，Done V，. 三种再矿化剂 - 生物活性玻璃、纳米羟基磷灰石和酪蛋白磷酸肽 - 无定形磷酸钙氟化物基糊剂对乳牙釉质侵蚀的比较评估：一项[具体研究类型未给出]研究。《国际临床儿科牙科学杂志》2025；18（4）：425 - 430。
