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炎症性肺部疾病:最新进展与挑战的临床与科学综述

Inflammatory lung diseases: a clinical and scientific review of the latest advances and challenges.

作者信息

Katamesh Ahmed A, Almansour Khaled, Hassoun Shimaa M, Sayed Ossama M, Break Mohammed Khaled Bin, Zaki Randa Mohammed, Afzal Obaid, Radwan Amr

机构信息

Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il, 81442, Saudi Arabia.

Department of Pharmacology, College of Pharmacy, University of Ha'il, Ha'il, 81442, Saudi Arabia.

出版信息

Pharmacol Rep. 2025 Jun 13. doi: 10.1007/s43440-025-00749-y.

Abstract

Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary sarcoidosis, and interstitial lung diseases (ILDs), represent a significant cause of morbidity and mortality globally. These conditions are characterized by chronic inflammation and tissue damage, leading to substantial respiratory compromise and impairing quality of life. This review aims to provide a comprehensive overview of pathogenesis, clinical features, and diagnostic approaches for inflammatory lung diseases, emphasizing their shared and distinct characteristics. The review synthesizes current literature on the genetic predisposition, environmental exposures, and immune responses involved in the development and progression of inflammatory lung diseases. It also examines the classification and staging of these conditions to highlight the importance of accurate diagnosis and effective management. Key findings include the complex interplay of numerous factors that contribute to disease development and progression, as well as an analysis of classification and staging systems that support clinical practice. By elucidating the underlying mechanisms and clinical features of inflammatory lung diseases, this review aims to inform the development of novel therapeutic strategies and enhance patient outcomes.

摘要

炎症性肺部疾病,包括慢性阻塞性肺疾病(COPD)、哮喘、肺结节病和间质性肺疾病(ILDs),是全球发病和死亡的重要原因。这些病症的特点是慢性炎症和组织损伤,导致严重的呼吸功能障碍并损害生活质量。本综述旨在全面概述炎症性肺部疾病的发病机制、临床特征和诊断方法,强调它们的共同特征和独特特征。该综述综合了关于炎症性肺部疾病发生和发展过程中涉及的遗传易感性、环境暴露和免疫反应的当前文献。它还研究了这些病症的分类和分期,以突出准确诊断和有效管理的重要性。主要发现包括促成疾病发生和发展的众多因素之间的复杂相互作用,以及对支持临床实践的分类和分期系统的分析。通过阐明炎症性肺部疾病的潜在机制和临床特征,本综述旨在为新型治疗策略的开发提供信息并改善患者预后。

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