Tokuyama K, Tamura H, Mitsuhashi M, Morikawa A, Mochizuki H, Tajima K, Kuroume T
Ann Allergy. 1985 Oct;55(4):601-4.
Nine healthy and seven mite-sensitive allergic subjects were examined by skin sensitivity and IgE antibody to fractions from Dermatophagoides farinae, including high and low allergenic fraction to human. In the intracutaneous test, all healthy subjects reacted to 200 ng and in particular, five of them to 0.2 ng of Fr void on Sephadex G-100 filtration which was a low allergenic fraction. Furthermore, end points of intracutaneous test and specific IgE antibody titers did not correlate on Fr void. Conclusively, Dermatophagoides farinae extracts contain a nonimmunologically highly skin-reactive fraction.
对9名健康受试者和7名螨敏感过敏受试者进行了皮肤敏感性检测以及针对粉尘螨各组分的IgE抗体检测，这些组分包括对人类具有高、低致敏性的组分。在皮内试验中，所有健康受试者对200 ng的剂量均有反应，特别是其中5名受试者对经Sephadex G - 100过滤得到的低致敏性组分Fr void的0.2 ng剂量有反应。此外，皮内试验的终点与Fr void上的特异性IgE抗体滴度不相关。总之，粉尘螨提取物含有一种非免疫性的高皮肤反应性组分。
