A bibliometric review and visualization of research on myocardial ischemia/reperfusion injury in patients with diabetes mellitus from 2004 to 2024.

BACKGROUND

The incidence of diabetes mellitus (DM) is increasing annually, and hearts of patients with DM are more sensitive to myocardial ischemia/reperfusion (MI/R) injury. However, the specific mechanisms remain unknown. Through a bibliometric analysis of published research, this study primarily summarizes and clarifies the current status of research on diabetic MI/R injury.

METHODS

Publications related to MI/R injury in DM from January 1, 2004, to July 31, 2024, were obtained by searching the Web of Science Core Collection. The bibliometric method was adopted using Excel 2021, CiteSpace, VOSviewer, Pajek and the R package "Bibliometrix."

RESULTS

In total, 634 research papers and 221 reviews were published during this period that fit the criteria. The number of annual scientific publications and citations on diabetic MI/R injury has steadily increased. The majority of these studies were published by 1164 institutions from 70 countries, with China and the United States ranking first and second, respectively, in terms of publication volume. Among the leading institutions in this field, the Air Force Military Medical University, Wuhan University, and the University of Hong Kong were found to occupy the top positions. Keyword analysis reveals that recent research hotspots include antidiabetic agents, anesthetics and extracellular vesicles. Emerging trends such as ferroptosis, mitophagy, and gut microbiota are closely related to future research directions.

CONCLUSION

This study provided a detailed overview of the key contributors, institutions, and countries, highlighting the changes and progression of hotspots in diabetic MI/R injury. China leads the world in paper production; however, international cooperation is essential for enhancing the quality of research. In our study, we found that bibliometric analysis and literature visualization will help investigators gain a deeper understanding of the progress in the research into diabetic MI/R injury.