Thompson P J, Dhillon D P, Ledingham J, Turner-Warwick M
Am Rev Respir Dis. 1985 Oct;132(4):926-8. doi: 10.1164/arrd.1985.132.4.926.
One of the more unusual respiratory manifestations of systemic lupus erythematosus is "shrinking lungs." We report a patient with this syndrome and provide evidence for this being due to diaphragm dysfunction. Significant improvement occurred after albuterol therapy, providing new possibilities in the treatment of this syndrome. This is the first report in humans supporting animal work demonstrating that beta-agonists can improve diaphragmatic performance.
系统性红斑狼疮较为罕见的呼吸道表现之一是“肺萎陷”。我们报告了一名患有该综合征的患者，并提供证据表明这是由膈肌功能障碍所致。使用沙丁胺醇治疗后病情显著改善，为该综合征的治疗提供了新的可能性。这是首份支持动物实验结果的人体报告，表明β受体激动剂可改善膈肌功能。
