Kirkham Frances A, Shwe Phu Sabei, Mensah Ekow, Rajkumar Chakravarthi
Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Brighton and University of Sussex, Brighton, BN1 9PX, UK.
Department of Stroke Medicine, University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital, Brighton, BN2 5BE, UK.
Eur Geriatr Med. 2025 Jun 13. doi: 10.1007/s41999-025-01244-6.
AIMS/INTRODUCTION: Cytomegalovirus (CMV) is a highly prevalent virus, known to be associated with cardiovascular morbidity. It has been hypothesised to play a role in the development of frailty, but its association with physical function and sarcopenia has yet to be fully understood. This study aimed to look at the relationship between CMV, sarcopenia and health-related quality of life in older adults.
210 people in the south of England, UK, with median age 68 years (49% male, 51% female) underwent demographic and medical questionnaires, measures of body composition (bioimpedance analysis), handgrip strength and the short form 36 item survey of quality of life (SF36). All participants had CMV serology and inflammatory markers measured. Measures of sarcopenia were calculated using European Working Group definitions.
51.7% of participants were positive for CMV Immunoglobulin G (IgG). There were no significant differences between CMV positive and negative groups in age, gender, measures of sarcopenia or inflammatory markers. CMV positive groups had lower scores in all domains of the SF36, with significantly lower physical function score (88.7 vs 81.3, p = 0.003) as well as limitations due to physical health, energy/fatigue, social functioning and pain. On linear regression, CMV status was significantly associated with SF36 physical function score (p = 0.004) after adjustment for age, gender, body mass index, C-reactive protein and handgrip strength.
CMV positivity is significantly associated with physical function and health-related quality of life in older adults, although its direct relationship to sarcopenia is yet to be fully ascertained.
目的/引言：巨细胞病毒（CMV）是一种高度流行的病毒，已知与心血管疾病有关。据推测，它在衰弱的发展中起作用，但其与身体功能和肌肉减少症的关联尚未完全明确。本研究旨在探讨老年人中CMV、肌肉减少症与健康相关生活质量之间的关系。
英国英格兰南部的210人，中位年龄68岁（男性49%，女性51%），接受了人口统计学和医学问卷、身体成分测量（生物电阻抗分析）、握力测量以及生活质量简短36项调查问卷（SF36）。所有参与者均进行了CMV血清学和炎症标志物检测。使用欧洲工作组的定义计算肌肉减少症的测量值。
51.7%的参与者CMV免疫球蛋白G（IgG）呈阳性。CMV阳性和阴性组在年龄、性别、肌肉减少症测量值或炎症标志物方面无显著差异。CMV阳性组在SF36的所有领域得分较低，身体功能得分显著更低（88.7对81.3，p = 0.003），以及在身体健康、能量/疲劳、社会功能和疼痛方面存在限制。在线性回归分析中，在调整年龄、性别、体重指数、C反应蛋白和握力后，CMV状态与SF36身体功能得分显著相关（p = 0.004）。
CMV阳性与老年人的身体功能和健康相关生活质量显著相关，尽管其与肌肉减少症的直接关系尚未完全确定。
