姜黄素与胡椒碱联合应用对脓毒症危重症患者的治疗效果：一项随机双盲对照试验
Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial.
作者信息
Alikiaii Babak, Khatib Narges, Badpeyma Mohaddeseh, Hasanzadeh Esmat, Abbasi Saeed, Amini Sepide, Kiani Zahra, Hassanizadeh Shirin, Iraj Zahra, Sahebkar Amirhossein, Majeed Anju, Bagherniya Mohammad
机构信息
Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Trials. 2025 Jun 14;26(1):205. doi: 10.1186/s13063-025-08916-5.
BACKGROUND
Sepsis, an organ dysfunction caused by deregulated host response to infection, is a major health problem worldwide. Sepsis is associated with high rates of mortality, especially in critically ill patients. Curcumin may improve sepsis through its anti-inflammatory and antioxidant effects. This study aimed to investigate the effects of curcumin-piperine administration in critically ill septic patients.
METHOD
This double-blind randomized controlled trial (RCT) conducted on 66 patients with sepsis hospitalized in the intensive care unit (ICU). Patients were randomized to either the intervention group receiving two tablets of curcumin-piperine (each containing 500 mg curcuminoids and 5 mg piperine) (n = 33), or the placebo group receiving two matched tablets of placebo (n = 33) daily for 7 consecutive days along with enteral feeding. Clinical, laboratory, and biochemical indices were evaluated before and after the intervention. Statistical analyses were performed based on an intention-to-treat method.
RESULT
Mortality was observed in 10 patients in the curcumin-piperine group, and 12 patients in the control group. Curcumin-piperine significantly reduced bilirubin-total (P = 0.02), bilirubin-direct (P = 0.02), pH (P < 0.001), C-reactive protein (P = 0.04), erythrocyte sedimentation rate (P < 0.001), and platelet count (P = 0.01) compared with the placebo. A significantly lower reduction was found in red blood cell (P = 0.003), hemoglobin (P = 0.001), and hematocrit (P = 0.002) levels in the intervention vs. placebo group. In addition, mean corpuscular hemoglobin (P < 0.001) and mean corpuscular hemoglobin concentration (P = 0.001) were significantly higher in the intervention vs. placebo group.
CONCLUSION
Curcumin-piperine supplementation over a short period had beneficial effects on some inflammatory and laboratory indices in critically ill patients with sepsis.
TRIAL REGISTRATION
IRCT20150613022681N4; available on: https://en.irct.ir/trial/52661 . Registration date: 2021-01-02, 1399/10/13.
背景
脓毒症是宿主对感染的反应失调引起的器官功能障碍，是全球主要的健康问题。脓毒症与高死亡率相关，尤其是在危重症患者中。姜黄素可能通过其抗炎和抗氧化作用改善脓毒症。本研究旨在探讨姜黄素 - 胡椒碱给药对危重症脓毒症患者的影响。
方法
本双盲随机对照试验（RCT）对66例入住重症监护病房（ICU）的脓毒症患者进行。患者被随机分为干预组，接受两片姜黄素 - 胡椒碱（每片含500毫克姜黄素类化合物和5毫克胡椒碱）（n = 33），或安慰剂组，接受两片匹配的安慰剂（n = 33），连续7天每日服用，同时进行肠内喂养。在干预前后评估临床、实验室和生化指标。基于意向性分析方法进行统计分析。
结果
姜黄素 - 胡椒碱组有10例患者死亡，对照组有12例患者死亡。与安慰剂相比，姜黄素 - 胡椒碱显著降低了总胆红素（P = 0.02）、直接胆红素（P = 0.02）、pH值（P < 0.001）、C反应蛋白（P = 0.04）、红细胞沉降率（P < 0.001）和血小板计数（P = 0.01）。与安慰剂组相比，干预组红细胞（P = 0.003）、血红蛋白（P = 0.001）和血细胞比容（P = 0.002）水平的降低幅度明显较小。此外，干预组的平均红细胞血红蛋白含量（P < 0.001）和平均红细胞血红蛋白浓度（P = 0.001）显著高于安慰剂组。
结论
短期补充姜黄素 - 胡椒碱对危重症脓毒症患者的一些炎症和实验室指标有有益影响。
试验注册
IRCT20150613022681N4；可在：https://en.irct.ir/trial/52661 上获取。注册日期：2021年1月2日，1399/10/13。
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