Te Tue T, Bui Alex A T, Fung Constance H, Boland Mary Regina
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Geriatric, Research, Education and Clinical Center, VA Greater Los Angeles, Los Angeles, CA, USA.
BioData Min. 2025 Jun 13;18(1):41. doi: 10.1186/s13040-025-00456-7.
There is evidence of increased risk of cognitive disability due to short sleep duration and adverse Social Determinants of Health (SDoH). To determine whether spatial associations (correlation between spatially distributed variables within a given geographic area) exist between neighborhoods with short sleep duration and cognitive disability across the United States (US) after adjusting for other factors. We conducted a spatial analysis using a spatial lag model at the neighborhood-level with the census tract as unit-of-analysis within each state in the US. We aggregated our results nationally using a weighted analysis to adjust for the number of census tracts per state. This study used Centers for Disease Control and Prevention (CDC) data on short sleep duration, cognitive disability and other health factors. We used 2021-2022 neighborhood-level data from the CDC and US Census Bureau adjusting for social determinants of health (SDoH) and demographics, excluding Florida due to inconsistencies in data availability. Our exposure variable was self-reported short sleep defined by the CDC ("sleep less than 7 hours per 24 hour period"). Our outcome was self-reported cognitive disability defined by the CDC ("difficulty concentrating, remembering, or making decision"). We adjusted for other factors including 'health outcomes', 'preventive practices', and the CDC's Social Vulnerability Index.
The spatial analysis revealed a significant association between short sleep duration and an increased risk of cognitive disability across the US (estimate range [0.29; 1.27], p < 0.005) after adjustment. Notably, six Western states (New Mexico, Alaska, Arizona, Nevada, Idaho, and Oregon) were at increased risk of cognitive disability due to short sleep duration and this pattern was significant (p = 0.007).
Our study highlights the importance of short sleep duration as a significant predictor of cognitive disability across the US after adjusting for other confounders. The association between short sleep and cognitive disability was especially strong in the Western region of the US providing a deeper understanding of how geographic context and local factors can shape health outcomes.
有证据表明,睡眠时长较短以及不良的健康社会决定因素(SDoH)会增加认知障碍的风险。为了确定在美国,在调整其他因素后,睡眠时长较短的社区与认知障碍之间是否存在空间关联(给定地理区域内空间分布变量之间的相关性)。我们在美国每个州以普查区为分析单位,在社区层面使用空间滞后模型进行了空间分析。我们使用加权分析在全国范围内汇总结果,以调整每个州的普查区数量。本研究使用了疾病控制与预防中心(CDC)关于睡眠时长较短、认知障碍和其他健康因素的数据。我们使用了来自CDC和美国人口普查局的2021 - 2022年社区层面数据,对健康社会决定因素(SDoH)和人口统计学进行了调整,由于数据可用性不一致,排除了佛罗里达州。我们的暴露变量是由CDC定义的自我报告的短睡眠(“每24小时睡眠少于7小时”)。我们的结果是由CDC定义的自我报告的认知障碍(“注意力不集中、记忆力差或做决定困难”)。我们对其他因素进行了调整,包括“健康结果”、“预防措施”以及CDC的社会脆弱性指数。
空间分析显示,在美国,调整后睡眠时长较短与认知障碍风险增加之间存在显著关联(估计范围[0.29;1.27],p < 0.005)。值得注意的是,六个西部州(新墨西哥州、阿拉斯加州、亚利桑那州、内华达州、爱达荷州和俄勒冈州)因睡眠时长较短而面临认知障碍风险增加,且这种模式具有显著性(p = 0.007)。
我们的研究强调了在调整其他混杂因素后,睡眠时长较短作为美国认知障碍的一个重要预测因素的重要性。短睡眠与认知障碍之间的关联在美国西部地区尤为强烈,这为深入理解地理背景和当地因素如何影响健康结果提供了依据。