Daurenbekova A S, Vetlugina L A
Antibiot Med Biotekhnol. 1985 Jul;30(7):525-9.
Isolation, purification and chemical identification of an antibiotic produced by strain IMV A-23/791 of Streptomyces roseoflavus and its adifferentiated variant are described. The antibiotic inhibits the growth of many phytopathogenic fungi, dermatophytes and yeast-like fungi and is capable of stimulating the growth and development of plants. The antibiotic is effective in control of cucumber root rot under hydroponic cultivation conditions. It was shown that the adifferentiated proactinomycetous variant 4-76 was more productive than the initial strain A-23/791. The antibiotic isolated from the variant mycelium is more active. It was shown that the antibiotic can be isolated from the biomass of the adifferentiated variant with a more simple method in the authors' modification providing higher antibiotic yields and the use of lower amounts of the solvents. The UV, IR, mass and luminescence spectra and mobility in paper and thin-layer chromatography have shown the carbonyl-conjugated pentaene A-23/791 to be identical to roseofungin described earlier. Based on the data obtained strain A-23/791 should be classified with Streptomyces roseoflavus var, roseofungini Nikitina, 1968, a variant of Streptomyces roseoflavus Arai, 1951.
描述了从玫瑰黄链霉菌IMV A - 23/791菌株及其分化变体产生的一种抗生素的分离、纯化和化学鉴定。该抗生素能抑制多种植物病原真菌、皮肤真菌和类酵母真菌的生长，并能刺激植物的生长和发育。在水培条件下，该抗生素对黄瓜根腐病有防治效果。结果表明，分化的原放线菌变体4 - 76比初始菌株A - 23/791的产量更高。从变体菌丝体中分离出的抗生素活性更强。结果表明，在作者改进的方法中，可以用更简单的方法从分化变体的生物量中分离出抗生素，从而提高抗生素产量并减少溶剂用量。紫外、红外、质谱和发光光谱以及纸层析和薄层层析中的迁移率表明，羰基共轭戊二烯A - 23/791与先前描述的玫瑰霉素相同。根据所获得的数据，菌株A - 23/791应归类为玫瑰黄链霉菌玫瑰霉素变种（Nikitina，1968），它是玫瑰黄链霉菌（Arai，1951）的一个变种。
