非编码RNA在川崎病中的诊断意义：一项系统评价与Meta分析
Diagnostic significance of noncoding RNAs in kawasaki disease: A systematic review and meta-analysis.
作者信息
Zhong Xiaoling, Jia Xufeng, Wang Hui, Chen Guihua, Li Hongxia, Li Pingping, Yang Taoyi, Xie Jiang
机构信息
Department of Pediatrics, The Third People's Hospital of Chengdu/The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
出版信息
Front Pediatr. 2023 Jan 16;10:1071434. doi: 10.3389/fped.2022.1071434. eCollection 2022.
OBJECTIVE
Kawasaki disease (KD) is a systemic vasculitis disease, and early effective intervention would reduce the occurrence of coronary artery lesions (CALs). Recently, many scholars have been committed to studying the relationship between noncoding RNAs and KD. This systematic review aimed to analyze the diagnostic value of noncoding RNAs(ncRNAs) in distinguishing different KD status.
METHODS
We searched for the literature about diagnostic values of ncRNAs in KD in CNKI, VIP, Wanfang, China Biomedical Literature Database as well as PubMed, Web of Science, Embase, and Cochrane Library up to April 15, 2022. All included studies were further analyzed using STATA 12.0, Meta-disc 1.4 and RevMan 5.4 software.
RESULTS
A total of six studies investigating the diagnostic performance of ncRNAs in differentiating KD-CAL ( = 101) from KD-NCAL patients ( = 123) were included in this this meta-analysis. The calculated area under the curve(AUC) was 0.83 (0.80-0.86). Four studies on the diagnostic performance of ncRNAs in differentiating acute KD patients ( = 139) from convalescent KD patients ( = 109) were included. The calculated AUC was 0.87 (0.84-0.90). Four studies focused on the diagnostic performance of ncRNAs combined with other laboratory indexes in KD by assessing 137 KD patients and 152 febrile controls. The calculated AUC was 0.90 (0.87-0.92). Four studies assessed the diagnostic performance of ncRNAs in differentiating intravenous immunoglobulin (IVIG)-resistant KD patients from IVIG-responsive KD patients. The calculated AUC was 0.9135 ± 0.0307. These results indicated that ncRNAs have a good diagnostic efficacy in KD.
CONCLUSIONS
This meta-analysis showed that ncRNAs have potential as a biomarker for distinguishing different KD status. However, since limited studies were included in this meta-analysis, larger and well-designed diagnostic studies should be conducted to validate these results.
SYSTEMATIC REVIEW REGISTRATION
INPLASY.COM, identifier: doi: 10.37766/inplasy2022.10.0035.
目的
川崎病（KD）是一种全身性血管炎疾病，早期有效干预可减少冠状动脉病变（CALs）的发生。近年来，许多学者致力于研究非编码RNA与KD的关系。本系统评价旨在分析非编码RNA（ncRNAs）在区分不同KD状态中的诊断价值。
方法
检索中国知网、维普、万方、中国生物医学文献数据库以及PubMed、Web of Science、Embase和Cochrane图书馆中截至2022年4月15日关于ncRNAs在KD中诊断价值的文献。所有纳入研究均使用STATA 12.0、Meta-disc 1.4和RevMan 5.4软件进行进一步分析。
结果
本荟萃分析共纳入6项研究，这些研究调查了ncRNAs在区分KD合并CAL患者（n = 101）与KD无CAL患者（n = 123）中的诊断性能。计算得到的曲线下面积（AUC）为0.83（0.80 - 0.86）。纳入了4项关于ncRNAs在区分急性KD患者（n = 139）与恢复期KD患者（n = 109）中诊断性能的研究。计算得到的AUC为0.87（0.84 - 0.90）。4项研究通过评估137例KD患者和152例发热对照，聚焦于ncRNAs联合其他实验室指标在KD中的诊断性能。计算得到的AUC为0.90（0.87 - 0.92）。4项研究评估了ncRNAs在区分静脉注射免疫球蛋白（IVIG）抵抗性KD患者与IVIG反应性KD患者中的诊断性能。计算得到的AUC为0.9135 ± 0.0307。这些结果表明ncRNAs在KD中具有良好的诊断效能。
结论
本荟萃分析表明，ncRNAs有潜力作为区分不同KD状态的生物标志物。然而，由于本荟萃分析纳入的研究有限，应开展更大规模且设计良好的诊断性研究以验证这些结果。
系统评价注册
INPLASY.COM，标识符：doi: 10.37766/inplasy2022.10.0035 。
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