从串珠镰刀菌NRRL 13163中分离并鉴定两种新的镰刀菌酸类似物。
Isolation and characterization of two new fusaric acid analogs from Fusarium moniliforme NRRL 13,163.
作者信息
Burmeister H R, Grove M D, Peterson R E, Weisleder D, Plattner R D
出版信息
Appl Environ Microbiol. 1985 Aug;50(2):311-4. doi: 10.1128/aem.50.2.311-314.1985.
Abstract
Fusarium moniliforme NRRL 13,163 produced two new fusaric acid analogs, a 10,11-dihydroxyfusaric acid and a diacid of fusaric acid in which the C-11 methyl was oxidized to a carboxyl. Several hundred milligrams of the 10,11-dihydroxyfusaric acid were routinely recovered from a kilogram of corn grit medium. It crystallized as white, irregularly shaped rectangles that melted at 153 to 154 degrees C. The diacid analog of fusaric acid crystallized as white rods that melted at 210 to 211 degrees C. Unlike the consistent recovery experienced with the 10,11-dihydroxyfusaric acid, the diacid analog proved difficult to purify after the initial discovery and was detectable in subsequent fermentations only by mass spectrometry.
摘要
串珠镰刀菌NRRL 13163产生了两种新的镰刀菌酸类似物，一种是10,11 - 二羟基镰刀菌酸，另一种是镰刀菌酸的二酸，其中C - 11甲基被氧化成羧基。从一千克玉米粗粉培养基中通常能回收几百毫克的10,11 - 二羟基镰刀菌酸。它结晶为白色、形状不规则的矩形，熔点为153至154摄氏度。镰刀菌酸的二酸类似物结晶为白色棒状，熔点为210至211摄氏度。与10,11 - 二羟基镰刀菌酸的稳定回收情况不同，二酸类似物在最初发现后难以纯化，仅在后续发酵中通过质谱法才能检测到。
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