Buehler J W, Kuritsky J N, Gorman G W, Hightower A W, Broome C V, Sikes R K
Arch Environ Health. 1985 Jul-Aug;40(4):207-10. doi: 10.1080/00039896.1985.10545919.
A serosurvey for antibodies to Legionella pneumophila was conducted among 206 employees of a power-generating plant. L. pneumophila serotype 6 and a non-typable L. pneumophila organism were isolated from cooling-tower water specimens at the plant, and antibody titers in workers were measured using homologous antigens prepared from these isolates. For the serotype 6 water isolate, none of workers with low cooling tower exposure, 4.6% with intermediate exposure, and 7.6% with high exposure levels had titers equal to or greater than 1:128 (P less than .05, Kruskal-Wallis test). For the non-typable L. pneumophila isolate, a similar trend was observed, but differences among workers in the three exposure groups were not statistically significant. No association was observed between antibodies to L. pneumophila serotypes isolated from cooling water and workers' age, race, smoking status, or duration of job assignment. None of the study employees had findings suggesting the occurrence of L. pneumophila pneumonia since the plant had been in operation. Use of respiratory protection devices by workers exposed to aerosols from cooling towers was not recommended.
对一家发电厂的206名员工进行了针对嗜肺军团菌抗体的血清学调查。从该工厂的冷却塔水样中分离出嗜肺军团菌血清型6和一种不可分型的嗜肺军团菌菌株，并使用从这些分离株制备的同源抗原测量了工人的抗体滴度。对于血清型6的水分离株，冷却塔低暴露水平的工人中无人抗体滴度等于或大于1:128，中度暴露的工人中有4.6%，高暴露水平的工人中有7.6%（Kruskal-Wallis检验，P<0.05）。对于不可分型的嗜肺军团菌分离株，观察到类似趋势，但三个暴露组工人之间的差异无统计学意义。未观察到从冷却水中分离出的嗜肺军团菌血清型抗体与工人的年龄、种族、吸烟状况或工作年限之间存在关联。自工厂运营以来，研究中的员工均未出现提示嗜肺军团菌肺炎发生的迹象。不建议接触冷却塔气溶胶的工人使用呼吸防护装置。
