Gangil Prachi, Paul Manash K, B Prathyoosha, Mondal Debadrita, Kumari Sneha, Prasad P R, K E Vandana, Bisht Bharti, Mukhopadhyay Chiranjay
Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Virulence. 2025 Dec;16(1):2505698. doi: 10.1080/21505594.2025.2505698. Epub 2025 Jun 14.
Melioidosis, a fatal tropical disease, presents a wide array of clinical manifestations, including abscesses, pneumonia, septic shock, bacteraemia, osteomyelitis, septic arthritis, and skin infection. The Centers for Disease Control and Prevention (CDC) has classified (), a gram-negative bacterium found in soil, as a Tier 1 select agent. Referred to as the "great mimicker," this organism can infect several organs imitating the symptoms of different illnesses. According to worldwide data, there are around 165,000 cases and 89,000 deaths annually. Current diagnostic procedures rely primarily on culturing , are slow and have low sensitivity, resulting in delayed treatment and higher fatality rates. This review examines the substantial difficulties related to diagnosing melioidosis in response to the urgent need for precise and prompt diagnosis. We have summarized the results of diagnostic kits that are currently sold in the market and assessed the market for melioidosis diagnostic kits.
类鼻疽是一种致命的热带疾病，临床表现多种多样，包括脓肿、肺炎、感染性休克、菌血症、骨髓炎、化脓性关节炎和皮肤感染。美国疾病控制与预防中心（CDC）已将在土壤中发现的革兰氏阴性菌——类鼻疽杆菌列为一级选择生物制剂。这种微生物被称为“超级模仿者”，它可以感染多个器官，模仿不同疾病的症状。根据全球数据，每年约有16.5万例病例和8.9万例死亡。目前的诊断程序主要依赖于类鼻疽杆菌培养，速度慢且灵敏度低，导致治疗延迟和死亡率较高。鉴于迫切需要精确和快速的诊断，本综述探讨了与类鼻疽诊断相关的重大困难。我们总结了目前市场上销售的诊断试剂盒的结果，并评估了类鼻疽诊断试剂盒的市场情况。
