Rashid Amin Abdurrahman Abdul, Musa Marahaini, Nafi Siti Norasikin Mohd, Majid Nazia Abdul, Sulong Sarina
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.
Mol Biol Rep. 2025 Jun 14;52(1):594. doi: 10.1007/s11033-025-10704-y.
The ability to express replicative immortality is one of the hallmarks of cancer. Most of these cells attain this feature by expressing the enzyme telomerase. This enzyme is responsible for maintaining the telomeres, a repeating structure at the ends of chromosomes, protecting the chromosomes from degradation. The Paired Box (PAX) genes are a family of highly conserved genes involved in various functions, including the development of diseases like cancer, in which most of them express telomerase as the mechanism to maintain telomere length. This study seeks to investigate PAX genes as potential telomerase activators and explore emerging research areas. Related literature was retrieved from PubMed, Web of Science and Scopus databases using a keyword search, where 119 records were identified. However, upon further filtering, only four reports were relevant to this topic, which addresses the role of PAX5 and PAX8 genes and their proteins' role in telomerase regulation. More studies are needed to elucidate the complex mechanism of action between the PAX genes and telomerase regulation.
表达复制性永生的能力是癌症的标志之一。这些细胞中的大多数通过表达端粒酶获得这一特性。这种酶负责维持端粒，即染色体末端的重复结构，保护染色体不被降解。配对盒（PAX）基因是一类高度保守的基因，参与多种功能，包括癌症等疾病的发展，其中大多数PAX基因通过表达端粒酶作为维持端粒长度的机制。本研究旨在调查PAX基因作为潜在的端粒酶激活剂，并探索新兴的研究领域。通过关键词搜索从PubMed、科学网和Scopus数据库中检索相关文献，共识别出119条记录。然而，经过进一步筛选，只有四篇报告与本主题相关，该主题涉及PAX5和PAX8基因的作用及其蛋白质在端粒酶调控中的作用。需要更多的研究来阐明PAX基因与端粒酶调控之间复杂的作用机制。
