Rees R S, Altenbern D P, Lynch J B, King L E
Ann Surg. 1985 Nov;202(5):659-63. doi: 10.1097/00000658-198511000-00020.
In a prospective study, 31 patients with brown recluse spider bites were treated by either immediate surgical excision or with the leukocyte inhibitor, dapsone, followed by delayed surgical excision. Patients were matched for age, gender, and lesion size and were excluded if the typical history and physical findings were not present. In patients treated with immediate surgical excision (N = 14), delayed wound healing (N = 5) and objectional scarring (N = 7) were common complications. However, pretreatment treatment with dapsone reduced the incidence of wound complications (N = 1) and objectional scarring (N = 1) (p less than 0.05), while reducing the need for surgical excision (N = 1). There were no severe drug reactions due to dapsone, although one patient had persistent G.I. upset. Pretreatment with dapsone not only reduced surgical complications but also improved the outcome of patients bitten by the brown recluse spider.
在一项前瞻性研究中，31例棕色隐遁蛛咬伤患者接受了即时手术切除或使用白细胞抑制剂氨苯砜治疗，随后进行延迟手术切除。患者在年龄、性别和损伤大小方面进行了匹配，如果没有典型的病史和体格检查结果则被排除。在接受即时手术切除的患者（n = 14）中，伤口愈合延迟（n = 5）和明显瘢痕形成（n = 7）是常见的并发症。然而，氨苯砜预处理降低了伤口并发症（n = 1）和明显瘢痕形成（n = 1）的发生率（p < 0.05），同时减少了手术切除的需求（n = 1）。尽管有1例患者持续存在胃肠道不适，但未出现因氨苯砜引起的严重药物反应。氨苯砜预处理不仅减少了手术并发症，还改善了棕色隐遁蛛咬伤患者的预后。
