Hajo-Tello N, Dupont C, Wepierre J, Cohen Y, Miller R, Godfraind T
Arch Int Pharmacodyn Ther. 1985 Jul;276(1):35-43.
The Iboga alkaloid tabernanthine (80 microM) non-competitively antagonized contractions in both the rat aorta and mesenteric artery induced by cumulative additions of noradrenaline and calcium. Tabernanthine (8, 40 and 80 microM) antagonized the K+ depolarization-induced contractions of the aorta. Tabernanthine (80 microM) depressed the phasic component of contractions induced by a single maximal concentration (10 microM) of noradrenaline in Ca++ -free solution. Tabernanthine induced a negative inotropic effect in electrically stimulated myocardial tissue and a negative chronotropic effect in the perfused rat heart. Tabernanthine is a calcium entry blocker which also affects cellular calcium metabolism.
伊博加生物碱育亨宾碱（80微摩尔）非竞争性地拮抗了大鼠主动脉和肠系膜动脉中由去甲肾上腺素和钙的累积添加所诱导的收缩。育亨宾碱（8、40和80微摩尔）拮抗了主动脉中钾离子去极化诱导的收缩。育亨宾碱（80微摩尔）抑制了在无钙离子溶液中由单一最大浓度（10微摩尔）去甲肾上腺素诱导的收缩的时相成分。育亨宾碱在电刺激的心肌组织中诱导负性肌力作用，在灌注的大鼠心脏中诱导负性变时作用。育亨宾碱是一种钙通道阻滞剂，它也影响细胞钙代谢。
