Wang Yurong, Xu Peixin, Chen Hong, Guo Xin, Gao Jing, Wang Tong, Yao Dongmei, Li Xin, Liu Bingchun, Yuan Jianlong
Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Central Laboratory of Organ Transplantation/Stem Cell Laboratory/Inner Mongolia Autonomous Region Engineering Laboratory for Genetic Testing and Research of Tumour Cells, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Toxicology. 2025 Nov;517:154219. doi: 10.1016/j.tox.2025.154219. Epub 2025 Jun 16.
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that are hazardous to human health; can be produced by a variety of pathways; and are widely present in the environment, including air, soil, and water. When PAHs enter the human body, they accelerate cellular senescence and cellular ageing by promoting cell cycle arrest, inducing the excessive production of reactive oxygen species (ROS) and DNA methylation and mitochondrial dysfunction, thereby increasing the likelihood of disease, including reproductive disorders, Alzheimer's disease and cardiovascular diseases. Therefore, studying and combatting diseases caused by PAH exposure is critical. In this work, we elaborate on the mechanism of PAH toxicity and the diseases caused by PAHs from the perspective of the cellular senescence induced by PAHs, their central component benzo(a)pyrene, and their derivatives, with the aim of elucidating the molecular mechanisms of human diseases induced by PAHs through cellular senescence to provide theoretical support for the development of targeted preventive strategies and the maintenance of public health.
多环芳烃（PAHs）是对人体健康有害的环境污染物；可通过多种途径产生；并广泛存在于环境中，包括空气、土壤和水。当多环芳烃进入人体时，它们会通过促进细胞周期停滞、诱导活性氧（ROS）过度产生、DNA甲基化和线粒体功能障碍来加速细胞衰老和细胞老化，从而增加患病的可能性，包括生殖障碍、阿尔茨海默病和心血管疾病。因此，研究和对抗由多环芳烃暴露引起的疾病至关重要。在这项工作中，我们从多环芳烃、其核心成分苯并（a）芘及其衍生物诱导的细胞衰老角度阐述了多环芳烃毒性机制和由多环芳烃引起的疾病，旨在阐明通过细胞衰老由多环芳烃诱导的人类疾病的分子机制，为制定有针对性的预防策略和维护公众健康提供理论支持。
