Sapozhnikova L R
Arkh Anat Gistol Embriol. 1985 Jul;89(7):90-5.
Differences in the DNA synthesis dynamics (according to the label index-LI) and those of mitotic activity (MA) in the mesothelium of the rat parietal peritoneum have been studied after burn performed at 9 AM, or at 9 PM. A number of peculiarities in the regeneration character are dependent on the day time of the operation. Immediately after the PM operation inhibition of both DNA synthesis and MA is manifected more distinctly and lasts longer, but then activation of the processes occurs more intensively the LI and MA values are greater than after the AM operation. Drop in the LI and MA takes place also with a greater rate after the PM operation, but their absolute values are kept higher up to the 7th day. Despite the fact that the reaction after the AM operation is comparatively weak, it is more rhythmical: against the background of general dynamics the fluctuations are more distinctly manifested, their period is nearly similar to the circadian. Increase in the proliferative activity is accompanied with a widening of the zone, where the dividing cells are situated. After the PM operation the wavy character of the process is expressed only in the pattern of the spatial organization of the regenerating mesothelium: nearly at regular intervals the area of the MA distribution becomes widen or narrow in turn. Thus, the LI and MA dynamics in the regenerating mesothelium depend on the circadian phase of the organism's state at the moment of the operation.
研究了上午9点或晚上9点烧伤大鼠壁层腹膜间皮后，其DNA合成动力学（根据标记指数-LI）和有丝分裂活性（MA）的差异。再生特征的许多特殊性取决于手术的时间。下午手术刚结束后，DNA合成和MA的抑制表现得更明显且持续时间更长，但随后这些过程的激活更强烈，LI和MA值比上午手术后更高。下午手术后，LI和MA的下降速度也更快，但其绝对值在第7天前一直保持较高。尽管上午手术后的反应相对较弱，但更具节律性：在总体动态变化的背景下，波动表现得更明显，其周期与昼夜节律相近。增殖活性的增加伴随着分裂细胞所在区域的扩大。下午手术后，该过程的波浪状特征仅在再生间皮的空间组织模式中表现出来：几乎每隔一定时间，MA分布区域会依次变宽或变窄。因此，再生间皮中的LI和MA动态取决于手术时机体状态的昼夜节律阶段。
