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[将人类新皮质的胚胎原基移植到大鼠脑内]

[Transplantation of embryonal anlagen of the human neocortex into the brain of the rat].

作者信息

Otellin V A, Gilerovich E G, Gusikhina V I

出版信息

Arkh Anat Gistol Embriol. 1985 Aug;89(8):18-22.

PMID:4051786
Abstract

A possibility for transplanting anlages of human embryonal neocortex into mature rat brain has been studied. Light- and electron-microscopic investigations demonstrate that the embryonal tissue of the human neocortex implants into the cerebral grey and white substance of mature rats. In the grafts cellular elements proliferate and differentiate, neuropil is formed. These results open certain perspectives for modelling investigations on histogenesis of neural tissues and on studying possibilities for clinical use of grafts of the human embryonal brain.

摘要

对将人类胚胎新皮质原基移植到成年大鼠大脑中的可能性进行了研究。光镜和电镜研究表明,人类新皮质的胚胎组织植入到成年大鼠的大脑灰质和白质中。在移植组织中,细胞成分增殖并分化,形成神经毡。这些结果为神经组织组织发生的建模研究以及人类胚胎脑移植临床应用可能性的研究开辟了一定的前景。

相似文献

1
[Transplantation of embryonal anlagen of the human neocortex into the brain of the rat].[将人类新皮质的胚胎原基移植到大鼠脑内]
Arkh Anat Gistol Embriol. 1985 Aug;89(8):18-22.
2
[A comparative morphological study of homo- and heterotopic neural transplants].
Morfologiia. 1996;109(2):12-6.
3
[Structural basis of developmental changes in the cytoarchitecture of human neocortex transplants].
Arkh Anat Gistol Embriol. 1990 Oct;99(10):20-5.
4
[Homotopic transplantation of embryonic neocortical tissue into the brain of adult rats after its damage].
Arkh Anat Gistol Embriol. 1987 Dec;93(12):5-11.
5
[The cytodifferentiation of the rat spinal cord and neocortical neural elements when implanted into a peripheral nerve].[大鼠脊髓和新皮质神经元件植入周围神经后的细胞分化]
Tsitologiia. 1993;35(1):59-64.
6
[The histogenesis of embryonic neocortical allografts in rats under the action of cyclosporine A].[环孢素A作用下大鼠胚胎新皮质同种异体移植的组织发生]
Tsitologiia. 1996;38(7):696-702.
7
Ultrastructure of fetal spinal cord and cortex implants into adult rat spinal cord.植入成年大鼠脊髓的胎儿脊髓和皮质的超微结构
J Neurosci Res. 1984;11(4):359-72. doi: 10.1002/jnr.490110404.
8
[The ultrastructure of the neurons of a graft developing in the brain of rats experiencing hypoxia].[在经历缺氧的大鼠大脑中发育的移植物神经元的超微结构]
Ontogenez. 1990 Jul-Aug;21(4):395-402.
9
[Neuroglial differentiation in rat embryonal neocortical transplants, located in the brain of adult animals. An immunohistochemical study].
Dokl Akad Nauk SSSR. 1989;307(6):1487-9.
10
[The developmental characteristics of the embryonic anlagen of rat neocortex and spinal cord when transplanted into the distal end of the dissected sciatic nerve of adult animals].[大鼠新皮层和脊髓胚胎原基移植到成年动物坐骨神经切断端后的发育特征]
Tsitologiia. 1997;39(9):784-8.

引用本文的文献

1
The influence of immune suppression on the take rate and development of the human neocortex transplanted to the spinal cord of the adult rat.
Neurosci Behav Physiol. 1993 Sep-Oct;23(5):455-8. doi: 10.1007/BF01183007.
2
Implantation of embryonal brain tissue into regenerating peripheral nerve.
Neurosci Behav Physiol. 1989 Jul-Aug;19(4):313-7. doi: 10.1007/BF01236020.
3
Results of transplanting sections of the midbrain of human embryos into the brain of mature rats.将人类胚胎中脑切片移植到成年大鼠大脑中的结果。
Neurosci Behav Physiol. 1989 Sep-Oct;19(5):439-42. doi: 10.1007/BF01197879.
4
Transplantation of human embryonal nervous tissue into the spinal cord of adult rats.将人类胚胎神经组织移植到成年大鼠的脊髓中。
Neurosci Behav Physiol. 1991 May-Jun;21(3):193-8. doi: 10.1007/BF01191654.