Luo Chang-Kang, Lai Chun-Yan, Tan Jia-Hao, Zhao Wei, Tan Qing-Qing
Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 Sichuan Province, China; Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong 637000 Sichuan Province, China.
Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000 Sichuan Province, China; Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong 637000 Sichuan Province, China.
Photodiagnosis Photodyn Ther. 2025 Aug;54:104681. doi: 10.1016/j.pdpdt.2025.104681. Epub 2025 Jun 13.
To evaluate the differences in the efficacy of repeated low-level red-light (RLRL) therapy combined with either single-vision spectacles (SVS) or defocus incorporated multiple segments (DIMS) spectacles in slowing myopia progression in children.
A total of 129 myopic children aged 6-14 years were recruited between July 2023 and February 2024. Participants had at least one eye with spherical equivalent refraction (SER) <-0.50D and astigmatism ≤ 3.00D after cycloplegia. They were divided into four groups: SVS, DIMS, RLRL combined with SVS (RCS), and RLRL combined with DIMS (RCD). The RCS and RCD groups wore spectacles and received daily RLRL therapy sessions. The primary outcome was the change in axial length (AL) at 12 months.
After 12 months, the mean changes of AL were: 0.26 mm (95 % CI, 0.17 to 0.35 mm) for SVS, 0.16 mm (95 % CI, 0.11 to 0.21 mm) for DIMS, -0.21 mm (95 % CI, -0.45 to 0.02 mm) for RCS, and -0.14 mm (95 % CI, -0.27 to -0.01 mm) for RCD. Significant differences were observed between groups (F = 15.18, P < 0.001). Post-hoc tests showed that the RCS and RCD groups exhibited significantly greater shortening compared to the SVS and DIMS groups (all P < 0.001). However, no significant difference was observed between the RCS and RCD groups (P > 0.05). No severe adverse events or safety concerns related to RLRL therapy were observed throughout the study.
RLRL therapy is a potentially effective and practical approach for myopia control, demonstrating comparable efficacy when combined with either SVS or DIMS spectacles.
评估重复低强度红光（RLRL）疗法联合单焦点眼镜（SVS）或离焦型多焦点（DIMS）眼镜在减缓儿童近视进展方面的疗效差异。
2023年7月至2024年2月共招募了129名6至14岁的近视儿童。参与者在散瞳后至少有一只眼睛的等效球镜度（SER）<-0.50D且散光≤3.00D。他们被分为四组：SVS组、DIMS组、RLRL联合SVS组（RCS组）和RLRL联合DIMS组（RCD组）。RCS组和RCD组佩戴眼镜并接受每日RLRL治疗。主要结局是12个月时眼轴长度（AL）的变化。
12个月后，AL的平均变化为：SVS组0.26 mm（95%CI，0.17至0.35 mm），DIMS组0.16 mm（95%CI，0.11至0.21 mm），RCS组-0.21 mm（95%CI，-0.45至0.02 mm），RCD组-0.14 mm（95%CI，-0.27至-0.01 mm）。组间观察到显著差异（F = 15.18，P < 0.001）。事后检验表明，与SVS组和DIMS组相比，RCS组和RCD组的眼轴缩短明显更大（所有P < 0.001）。然而，RCS组和RCD组之间未观察到显著差异（P > 0.05）。在整个研究过程中，未观察到与RLRL治疗相关的严重不良事件或安全问题。
RLRL疗法是一种潜在有效且实用的近视控制方法，与SVS或DIMS眼镜联合使用时显示出相当的疗效。
