Vikhert A M, Cherpachenko N M
Arkh Patol. 1985;47(7):29-34.
Histochemical study of enzymatic activity in the myocardium was performed in sudden cardiac death. Human hearts in which there were no macroscopic and histological focal or diffuse changes served as material. The following enzymes were studied in the anterior or posterior walls of the left ventricle or in the interventricular septum: succinate dehydrogenase, lactate dehydrogenase (LDH), beta-hydroxybutyrate dehydrogenase (OHBDH), alpha-glycerophosphate- and glucose-6-phosphate dehydrogenase, NAD-diaphorase and phosphorylase. Increased activity of OHBDH and LDH was found: 36,0 and 22,6% higher than in trauma and brain hemorrhage that served as control. These alterations seem to be connected with the increase of blood content of fatty acids, and lactate as a response to the catecholamine excess. Foci of an acute ischemia were found in the interventricular septum in 80% of cases in which phosphorylase was revealed. The appearance of the ischemic foci was obviously due to the coronary arteries contraction.
对心脏性猝死患者的心肌进行了酶活性的组织化学研究。选取无宏观和组织学局灶性或弥漫性改变的人体心脏作为材料。在左心室前壁或后壁或室间隔中研究了以下几种酶：琥珀酸脱氢酶、乳酸脱氢酶（LDH）、β-羟丁酸脱氢酶（OHBDH）、α-甘油磷酸脱氢酶和葡萄糖-6-磷酸脱氢酶、NAD-黄递酶和磷酸化酶。发现OHBDH和LDH活性增加：分别比作为对照的创伤和脑出血高36.0%和22.6%。这些改变似乎与脂肪酸和乳酸血液含量的增加有关，这是对儿茶酚胺过量的一种反应。在80%显示有磷酸化酶的病例中，室间隔发现了急性缺血灶。缺血灶的出现显然是由于冠状动脉收缩所致。
