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[心脏性猝死时心肌的早期缺血性损伤]

[Early ischemic injuries of the myocardium in sudden cardiac death].

作者信息

Vikhert A M, Cherpachenko N M, Galakhov I E

出版信息

Arkh Patol. 1980;42(9):28-34.

PMID:7425869
Abstract

Hearts of 38 men dying suddenly of acute coronary insufficiency and autopsied within 3 hours after death were examined. Foci of acute ischemic injuries in different parts of the myocardium were studied by histochemical methods for which the activity of succinate dehydrogenase and phosphorylase were determined. Early ischemic lesions in the myocardium were found in 22 fatalities, of them 5 had acute myocardial infarction, in 9 foci of ischemia were combined with the presence of postinfarction scars and fine focal cardiosclerosis, in 8 cases foci of early ischemia were the only changes in the myocardium. The majority of the decreased had stenosing atherosclerosis of the coronary arteries. Localization of ischemia foci in the myocardium did not always correspond to the severity of stenosing or the presence of thrombosis of the artery supplying the corresponding parts of the heart muscle. No foci of ischemia in the myocardium were found in 16 decreased who also had quite marked coronary atherosclerosis.

摘要

对38名因急性冠状动脉供血不足而突然死亡且在死后3小时内进行尸检的男性心脏进行了检查。采用组织化学方法研究心肌不同部位的急性缺血性损伤灶,测定琥珀酸脱氢酶和磷酸化酶的活性。在22例死亡病例中发现心肌早期缺血性病变,其中5例有急性心肌梗死,9例缺血灶合并心肌梗死后瘢痕和微小局灶性心肌硬化,8例早期缺血灶是心肌的唯一改变。大多数死者有冠状动脉狭窄性动脉粥样硬化。心肌缺血灶的定位并不总是与供应相应心肌部位的动脉狭窄程度或血栓形成情况相符。16例死者虽有相当明显的冠状动脉粥样硬化,但未发现心肌缺血灶。

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