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罕见病例报告:宫颈腺癌肝转移伴囊性肿块及梗阻性黄疸。

Rare case report: Liver metastasis from cervical adenocarcinoma presenting with cystic mass and obstructive jaundice.

作者信息

Li Jin, Wei Xin, Luo Le

机构信息

Department of Ultrasound, Deyang People's Hospital, Deyang, Sichuan, China.

Medical Records Statistics Management Section, Deyang People's Hospital, Deyang, Sichuan, China.

出版信息

Front Oncol. 2025 May 30;15:1558946. doi: 10.3389/fonc.2025.1558946. eCollection 2025.

DOI:10.3389/fonc.2025.1558946
PMID:40519293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12162578/
Abstract

Liver metastases can originate from primary tumors in various organs; however, metastasis from cervical cancer to the liver is rare. Cervical cancer patients with distant metastases have a poor prognosis and reduced survival rates. This report describes a case of a cystic liver mass with obstructive jaundice, observed four years after resection of cervical adenocarcinoma. The lesion lacked typical imaging characteristics of hepatic metastases and was initially suspected to be a biliary neoplasm. A contrast-enhanced, ultrasound-guided needle biopsy was performed to confirm the diagnosis. Histopathological analysis confirmed adenocarcinoma of the liver, and immunohistochemical staining suggested a uterine or adnexal origin. Considering the patient's surgical history, the final diagnosis was liver metastasis originating from cervical adenocarcinoma. This report reviews relevant literature to discuss the clinical features, diagnostic challenges, and therapeutic strategies for liver metastasis of cervical cancer.

摘要

肝转移瘤可源自各种器官的原发性肿瘤;然而,宫颈癌转移至肝脏较为罕见。发生远处转移的宫颈癌患者预后较差,生存率降低。本报告描述了一例在宫颈腺癌切除术后四年观察到的伴有梗阻性黄疸的肝囊性肿块病例。该病变缺乏肝转移瘤的典型影像学特征,最初怀疑是胆道肿瘤。进行了超声引导下的对比增强针吸活检以确诊。组织病理学分析证实为肝腺癌,免疫组化染色提示起源于子宫或附件。考虑到患者的手术史,最终诊断为源自宫颈腺癌的肝转移。本报告回顾相关文献,以讨论宫颈癌肝转移的临床特征、诊断挑战及治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce8/12162578/3c569f18cbdf/fonc-15-1558946-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce8/12162578/27ac56239e49/fonc-15-1558946-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce8/12162578/3c569f18cbdf/fonc-15-1558946-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce8/12162578/27ac56239e49/fonc-15-1558946-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce8/12162578/3c569f18cbdf/fonc-15-1558946-g002.jpg

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Front Oncol. 2025 May 30;15:1558946. doi: 10.3389/fonc.2025.1558946. eCollection 2025.
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本文引用的文献

1
Distant organ metastasis patterns and prognosis of cervical adenocarcinoma: a population-based retrospective study.宫颈腺癌的远处器官转移模式及预后:一项基于人群的回顾性研究。
Front Med (Lausanne). 2024 May 30;11:1401700. doi: 10.3389/fmed.2024.1401700. eCollection 2024.
2
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据:全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
3
Incidence, prognostic factors and a nomogram of cervical cancer with distant organ metastasis: a SEER-based study.
伴有远处器官转移的宫颈癌的发病率、预后因素及列线图:一项基于监测、流行病学和最终结果(SEER)数据库的研究
J Obstet Gynaecol. 2023 Dec;43(1):2181690. doi: 10.1080/01443615.2023.2181690.
4
Hepatectomy for liver metastases from cervical cancer with portal vein tumor thrombosis: a case report.宫颈癌伴门静脉癌栓肝转移行肝切除术 1 例报告
Clin J Gastroenterol. 2022 Apr;15(2):441-445. doi: 10.1007/s12328-022-01603-x. Epub 2022 Feb 22.
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A Unique Finding of Hepatogastric Fistula in Cervical Cancer Liver Metastasis.宫颈癌肝转移中肝胃瘘的独特发现。
Cureus. 2021 Dec 27;13(12):e20761. doi: 10.7759/cureus.20761. eCollection 2021 Dec.
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Surgical Management of Gynecologic Cancers.妇科癌症的外科治疗。
Surg Oncol Clin N Am. 2021 Jan;30(1):69-88. doi: 10.1016/j.soc.2020.09.004.
7
Chemorefractory liver metastasis from cervical cancer successfully treated with a combination of yttrium-90 and immunotherapy.采用钇-90与免疫疗法联合治疗难治性宫颈癌肝转移取得成功。
Radiol Case Rep. 2020 Jun 26;15(8):1359-1365. doi: 10.1016/j.radcr.2020.06.010. eCollection 2020 Aug.
8
[Hepatic metastases after cervical cancer surgery: clinical analysis of 13 cases].[宫颈癌手术后肝转移:13例临床分析]
Zhonghua Fu Chan Ke Za Zhi. 2020 Apr 25;55(4):266-272. doi: 10.3760/cma.j.cn112141-20200114-00033.
9
Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis.子宫颈癌患者不同远处转移模式的预后:一项基于人群的分析。
J Cancer. 2020 Jan 14;11(6):1532-1541. doi: 10.7150/jca.37390. eCollection 2020.
10
Microwave ablation versus resection for colorectal cancer liver metastases - A propensity score analysis from a population-based nationwide registry.微波消融与切除术治疗结直肠癌肝转移的比较——基于全国人群登记数据库的倾向评分分析。
Eur J Surg Oncol. 2020 Mar;46(3):476-485. doi: 10.1016/j.ejso.2019.12.002. Epub 2019 Dec 2.