Hercules Kavari, Liu Zhiyuan, Christofilea Eleni, Wei Jia, Venegas Gladys, Ciocca Olivia, Dyer Alice, Lee Goeun, Santini-Bishop Sasha, Shappell Heather, Gee Dylan G, Sukhodolsky Denis G, Ibrahim Karim
Child Study Center, Yale University School of Medicine, New Haven, Connecticut.
Department of Social and Behavioral Sciences, Yale University School of Public Health, New Haven, Connecticut.
Biol Psychiatry Glob Open Sci. 2025 Apr 17;5(4):100506. doi: 10.1016/j.bpsgos.2025.100506. eCollection 2025 Jul.
It is unclear how transdiagnostic symptoms including attention, disruptive behavior, and internalizing problems are linked to in-scanner motion in children across structural and functional magnetic resonance imaging (fMRI). In the current study, we examined whether transdiagnostic symptoms of attention, disruptive behavior, and internalizing problems were associated with scanner motion in children during multimodal imaging.
In 9045 children ages 9 to 10 years in the ABCD (Adolescent Brain Cognitive Development) Study, logistic regression and linear mixed-effects models were used to examine associations between motion and behavior. Motion was indexed using ABCD Study quality control (QC) metrics and mean framewise displacement for T1- and T2-weighted structural, resting-state, and diffusion MRI; stop-signal task; monetary incentive delay task; and emotional n-back task. The Child Behavior Checklist was used as a continuous measure of symptom severity.
Greater severity of attention and disruptive behavior problems was associated with a lower likelihood of passing motion QC across imaging modalities, while increased internalizing severity was associated with a higher likelihood of passing. There was also an interaction between sex and attention-related problems in passing QC for T2-weighted and diffusion MRI scans. Increased attention and disruptive behavior problems were associated with increased mean motion, whereas increased internalizing problems were associated with decreased mean motion. Greater severity of attention problems was associated with worse performance across the fMRI tasks.
These findings have implications for advancing the development of computational and behavioral approaches for mitigating motion effects in youths, enhancing accessibility of imaging protocols and representativeness influences across child psychiatric disorders, and identifying brain-based biomarkers.
目前尚不清楚包括注意力、破坏性行为和内化问题在内的跨诊断症状如何与儿童在结构和功能磁共振成像（fMRI）中的扫描内运动相关联。在本研究中，我们考察了注意力、破坏性行为和内化问题的跨诊断症状是否与儿童在多模态成像期间的扫描运动有关。
在青少年大脑认知发展（ABCD）研究中的9045名9至10岁儿童中，使用逻辑回归和线性混合效应模型来考察运动与行为之间的关联。运动通过ABCD研究质量控制（QC）指标以及T1加权和T2加权结构、静息态和扩散MRI、停止信号任务、金钱激励延迟任务和情绪n-back任务的平均逐帧位移来衡量。儿童行为检查表被用作症状严重程度的连续测量指标。
注意力和破坏性行为问题的严重程度越高，在各种成像模态中通过运动QC的可能性越低，而内化问题严重程度增加则与通过的可能性越高相关。在T2加权和扩散MRI扫描的QC通过方面，性别与注意力相关问题之间也存在交互作用。注意力和破坏性行为问题增加与平均运动增加相关，而内化问题增加与平均运动减少相关。注意力问题的严重程度越高，在fMRI任务中的表现越差。
这些发现对于推进减轻青少年运动影响的计算和行为方法的发展、提高成像方案的可及性以及跨儿童精神障碍的代表性影响，以及识别基于大脑的生物标志物具有重要意义。
