Liu Xuehuan, Dou Baolei, Zhu Qingjun, Liu Chuanguo
The Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China.
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Pharmacol. 2025 May 30;16:1567552. doi: 10.3389/fphar.2025.1567552. eCollection 2025.
Acute pancreatitis (AP) is a common critical disease in clinical practice, characterized by acute onset, rapid progression, aggressive conditions, and high lethality. Pancreatic acinar cell death is a central event in the pathological process of AP and a key factor in determining the extent of local or systemic inflammatory injury and overall prognosis. Programmed cell death (PCD) is a form of active cell death regulated by multiple genes, including apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis. PCD plays a critical role in eliminating unwanted organisms and damaged cells, which is of great significance. Numerous studies have demonstrated a strong association between various forms of PCD and AP, and targeted interventions in PCD signaling pathways and key targets can influence the progression of AP. Furthermore, existing research indicates that natural products sourced from plants, fruits, and vegetables exhibit considerable potential in targeting and regulating PCD for the treatment of AP. Therefore, this paper focuses on summarizing the common types of PCD in AP and discusses the specific signaling pathways and key targets reported in the treatment of AP using natural products. This review aims to provide a reference for natural products in guiding AP treatment and to lay the foundation for developing new drugs to effectively prevent and manage AP.
急性胰腺炎（AP）是临床常见的危急重症，起病急、进展快、病情凶险、病死率高。胰腺腺泡细胞死亡是AP病理过程中的核心事件，也是决定局部或全身炎症损伤程度及总体预后的关键因素。程序性细胞死亡（PCD）是一种由多个基因调控的主动细胞死亡形式，包括凋亡、自噬、铁死亡、焦亡和坏死性凋亡。PCD在清除有害生物和受损细胞方面发挥着关键作用，具有重要意义。大量研究表明，多种形式的PCD与AP之间存在密切关联，对PCD信号通路和关键靶点进行靶向干预可影响AP的进展。此外，现有研究表明，来自植物、水果和蔬菜的天然产物在靶向和调节PCD以治疗AP方面具有相当大的潜力。因此，本文重点总结AP中PCD的常见类型，并探讨使用天然产物治疗AP时报道的具体信号通路和关键靶点。本综述旨在为天然产物指导AP治疗提供参考，并为开发有效预防和管理AP的新药奠定基础。
