Guo Wen, Zhang Xiaobin, Zhou Xin, Lan Wangpeng, Liu Jianqin, Liu Yali, Li Li, Li Zhi
Department of Spleen and Stomach Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou city, The Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, China.
Front Pharmacol. 2025 May 30;16:1549909. doi: 10.3389/fphar.2025.1549909. eCollection 2025.
Dachengqi decoction (DCQD) is a traditional Chinese medicine formula consisting of three botanical drugs and one mineral drug. It has anti-inflammatory, gastrointestinal motility, and microcirculation improvement effects. A large number of studies have shown that DCQD has a significant impact on the treatment of acute pancreatitis (AP). However, owing to the multi-component and multi-target characteristics of traditional Chinese medicine, it is difficult for modern scientists to understand the role of DCQD in treating AP. Therefore, We sorted out the literature data related to DCQD published in databases such as Web of Science, PubMed, and CNKI, and summarized the main metabolites of DCQD, including anthraquinones, flavonoids, lignans and other metabolites. The pharmacokinetic characteristics of the main metabolites entering the blood circulation are preliminarily summarized. Combining chemical analysis and network analysis, some metabolites in DCQD, such as emodin, rhein, and luteolin, may play important roles in the treatment of AP, and this review also summarizes the efficacy mechanisms of these metabolites. In brief, we have summarized the treatment of AP with DCQD from the aspects of metabolites, preliminary pharmacokinetic analysis, and efficacy mechanisms, to facilitate further understanding of the material basis of DCQD.
大承气汤（DCQD）是一种由三味植物药和一味矿物药组成的中药方剂。它具有抗炎、促进胃肠蠕动和改善微循环的作用。大量研究表明，大承气汤对急性胰腺炎（AP）的治疗有显著影响。然而，由于中药具有多成分、多靶点的特点，现代科学家难以理解大承气汤在治疗AP中的作用。因此，我们整理了Web of Science、PubMed和CNKI等数据库中发表的与大承气汤相关的文献数据，总结了大承气汤的主要代谢产物，包括蒽醌类、黄酮类、木脂素类等代谢产物。初步总结了进入血液循环的主要代谢产物的药代动力学特征。结合化学分析和网络分析，大承气汤中的大黄素、大黄酸、木犀草素等一些代谢产物可能在AP治疗中发挥重要作用，本综述还总结了这些代谢产物的作用机制。简而言之，我们从代谢产物、初步药代动力学分析和作用机制等方面总结了大承气汤治疗AP的情况，以促进对大承气汤物质基础的进一步理解。
