Dunn Gary, Taylor Matthew P
Microbiology and Cell Biology, Montana State University, Bozeman MT 59717.
Future Virol. 2025;20(3-4):113-123. doi: 10.1080/17460794.2025.2475669. Epub 2025 Mar 12.
The cells infected by a virus are critical determinants of infection and disease. These same susceptible cells can also provide a wide range of options for viral propagation. The type of cell used to produce a virus, i.e. the producer cell type, can change the macromolecular composition of viruses and other factors associated with viral inoculum independent of genetic selection. Changes in the post-translational modifications of viral proteins, virion protein and lipid composition, and the types of viral structures released from different producer cells have been observed for several virus families. These producer cell-dependent changes can have wide ranging consequences on subsequent infection by altering viral tropism, antigenicity, and overall infectious capacity. The changes imparted by the producer cell impact experimental outcomes and influence viral spread and disease . In this review, we discuss the literature documenting the effects that producer cell type has on the macromolecular composition and infectious properties of virions and viral inoculum. We discuss the evidence of producer cell-dependent changes on the outcome of infection and antigenicity from diverse viral families. These observations highlight the need to better understand the impact producer cell type has on viral infections and disease.
受病毒感染的细胞是感染和疾病的关键决定因素。这些同样易感的细胞也能为病毒传播提供多种选择。用于生产病毒的细胞类型，即生产细胞类型，可改变病毒的大分子组成以及与病毒接种物相关的其他因素，而与基因选择无关。对于几个病毒家族，已经观察到病毒蛋白翻译后修饰、病毒粒子蛋白和脂质组成的变化，以及从不同生产细胞释放的病毒结构类型的变化。这些依赖于生产细胞的变化可通过改变病毒嗜性、抗原性和整体感染能力，对后续感染产生广泛影响。生产细胞带来的变化会影响实验结果，并影响病毒传播和疾病。在本综述中，我们讨论了记录生产细胞类型对病毒粒子和病毒接种物的大分子组成及感染特性影响的文献。我们讨论了来自不同病毒家族的生产细胞依赖性变化对感染结果和抗原性影响的证据。这些观察结果凸显了更好地理解生产细胞类型对病毒感染和疾病影响的必要性。
