Tang Si-Yun, Wu Hui, Liu Meng-Ran, Li Jing, Lu Yi-Chen, Cao Rui-Li, Lu Gu-Qin, Li Xiao-Hua
Department of Endocrinology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137 China.
Department of Nutrition, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137 China.
J Diabetes Metab Disord. 2025 Jun 11;24(2):148. doi: 10.1007/s40200-025-01644-2. eCollection 2025 Dec.
To investigate the correlation between skeletal muscle mass to visceral fat area ratio (SVR), neutrophil/lymphocyte ratio (NLR) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).
246 T2DM patients who attended the outpatient clinics and wards of the Department of Endocrinology of the Seventh People's Hospital affiliated to Shanghai University of Traditional Chinese Medicine from June 2022 to March 2023 were selected as study subjects. General information of the study subjects was collected, body measurements were determined: height, weight, waist circumference, hip circumference, body mass index and waist-hip ratio (WHR) were calculated; biochemical indices were determined: NLR, fasting glucose (FPG), fasting insulin (FINS), and the homeostatic modeling was evaluated. Homeostatic Model Assessment of Insulin Resistance(HOMA-IR), and calculation of insulin sensitivity index (ISI). Skeletal muscle content (ASM), body fat mass(BMI), visceral fat area(VFA), and basal metabolism were determined by multifrequency bio resistive resistance method, and SVR were calculated. 82 cases in each group (50 males and 32 females) were divided into 3 groups according to the SVR level in three equal parts. Differences between groups were analyzed by one-way ANOVA. The correlation between NLR and SVR, HOMA-IR, ISI was analyzed using Pearson/Spearman correlation. Multiple linear regression analysis was used to analyze the relationship between SVR and IR.
Compared with the Q3 group, NLR, FINS, HOMA-IR were elevated in the Q1 and Q2 groups ( < 0.005), and ISI and SVR were decreased ( < 0.005). Correlation analysis showed that NLR was negatively correlated with SVR, and ISI ( < 0.005) and positively correlated with HOMA-IR ( < 0.005). Multiple linear regression analysis showed that SVR and HOMA-IR were independently correlated ( = 25.584, < 0.001); and SVR and HOMA-IR were independently correlated ( = 46.105, < 0.001).
SVR is correlated with IR in T2DM patients, suggesting that SVR has some clinical value for early warning of IR in T2DM.
探讨2型糖尿病（T2DM）患者骨骼肌质量与内脏脂肪面积比值（SVR）、中性粒细胞/淋巴细胞比值（NLR）与胰岛素抵抗（IR）之间的相关性。
选取2022年6月至2023年3月在上海中医药大学附属第七人民医院内分泌科门诊及病房就诊的246例T2DM患者作为研究对象。收集研究对象的一般资料，进行人体测量：测定身高、体重、腰围、臀围，计算体重指数和腰臀比（WHR）；测定生化指标：NLR、空腹血糖（FPG）、空腹胰岛素（FINS），并评估稳态模型。评估胰岛素抵抗的稳态模型评估（HOMA-IR），计算胰岛素敏感性指数（ISI）。采用多频生物电阻抗法测定骨骼肌含量（ASM）、体脂质量（BMI）、内脏脂肪面积（VFA）和基础代谢率，并计算SVR。根据SVR水平将每组82例（男性50例，女性32例）分为3组，每组各占三分之一。采用单因素方差分析比较组间差异。采用Pearson/Spearman相关性分析NLR与SVR、HOMA-IR、ISI之间的相关性。采用多元线性回归分析SVR与IR之间的关系。
与Q3组相比，Q1组和Q2组的NLR、FINS、HOMA-IR升高（<0.005），ISI和SVR降低（<0.005）。相关性分析显示，NLR与SVR、ISI呈负相关（<0.005），与HOMA-IR呈正相关（<0.005）。多元线性回归分析显示，SVR与HOMA-IR独立相关（=25.584，<0.001）；SVR与HOMA-IR独立相关（=46.105，<0.001）。
T2DM患者的SVR与IR相关，提示SVR对T2DM患者IR的早期预警具有一定的临床价值。
