Kast Mariella, Zayats Mykhaylo, Shafiee Shayan, Zhuk Sergiy, Hesthaven Jan S, Joshi Amit
MCSS, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
IBM Research - Europe, Dublin, Ireland.
Proc IEEE Int Symp Biomed Imaging. 2025 Apr;2025. doi: 10.1109/isbi60581.2025.10980828. Epub 2025 May 12.
Fluorescence Image Guided Surgery utilizes continuous wave epi-fluorescence measurements on the tissue surface to locate targets such as tumors or lymph nodes, but precise 3D localization of deep targets remains intractable due to the illposedness of the associated inverse problem. We propose a Fluorescence Diffuse Optical Tomography scheme which leverages the different contrast agent kinetics in malignant vs normal tissue and reconstructs the 3D tumor location from a time series of epi-fluorescence measurements. We conduct sequential synthetic experiments, which mimic the differential uptake and release profile of fluorescent dye ICG in tumors vs normal tissue and demonstrate for the first time that the proposed method can robustly recover targets up to 1cm deep and in the presence of realistic tumor-to-background ratios.
荧光图像引导手术利用组织表面的连续波落射荧光测量来定位肿瘤或淋巴结等目标，但由于相关逆问题的不适定性，深部目标的精确三维定位仍然难以解决。我们提出了一种荧光漫射光学层析成像方案，该方案利用恶性组织与正常组织中不同的造影剂动力学，并从落射荧光测量的时间序列中重建三维肿瘤位置。我们进行了一系列模拟实验，模拟了荧光染料吲哚菁绿（ICG）在肿瘤与正常组织中的不同摄取和释放情况，并首次证明了所提出的方法能够在存在实际肿瘤与背景比率的情况下，稳健地恢复深度达1厘米的目标。
