醛脱氢酶。一种在单一类型活性位点具有两种不同催化活性的酶。
Aldehyde dehydrogenase. An enzyme with two distinct catalytic activities at a single type of active site.
作者信息
Duncan R J
出版信息
Biochem J. 1985 Aug 15;230(1):261-7. doi: 10.1042/bj2300261.
Abstract
The evidence for and against the esterase and dehydrogenase active sites of aldehyde dehydrogenase being topologically distinct is examined. It is found that all the evidence (including all that previously amassed by others in favour of distinct binding domains) is actually consistent with, and in favour of, a single type of catalytic site having both activities. The existence of separate high-Km modulating sites for the enzyme is also questioned.
摘要
对醛脱氢酶酯酶和脱氢酶活性位点在拓扑结构上是否不同的支持和反对证据进行了研究。结果发现，所有证据（包括之前其他人收集的所有支持不同结合域的证据）实际上都与单一类型的具有两种活性的催化位点一致，并支持这一观点。同时也对该酶是否存在单独的高Km调节位点提出了质疑。
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