在谷胱甘肽存在的情况下，双硫仑使乙醛脱氢酶失活。
The inactivation of aldehyde dehydrogenase by disulfiram in the presence of glutathione.
作者信息
Kitson T M
出版信息
Biochem J. 1981 Oct 1;199(1):255-8. doi: 10.1042/bj1990255.
Abstract
It is shown that in vitro glutathione provides little protection of cytoplasmic aldehyde dehydrogenase against the inactivatory action of disulfiram. This observation provides support for the current explanation of how disulfiram acts in vivo. The results show that the disulfiram-sensitive thiol groups of aldehyde dehydrogenase have an unusually high reactivity; possible mechanisms by which this might arise are discussed.
摘要
结果表明，在体外，谷胱甘肽对胞质醛脱氢酶免受双硫仑的失活作用几乎没有保护作用。这一观察结果为双硫仑在体内作用的当前解释提供了支持。结果表明，醛脱氢酶对双硫仑敏感的巯基具有异常高的反应活性；讨论了可能导致这种情况的机制。
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