己烯雌酚和2,2'-二硫代二吡啶对醛脱氢酶的激活作用。
The activation of aldehyde dehydrogenase by diethylstilboestrol and 2,2'-dithiodipyridine.
作者信息
Kitson T M
出版信息
Biochem J. 1982 Oct 1;207(1):81-9. doi: 10.1042/bj2070081.
Abstract
- The activation of sheep liver cytoplasmic aldehyde dehydrogenase by diethylstilboestrol and by 2,2'-dithiodipyridine is described. The effects of the two modifiers are very similar with respect to variation with acetaldehyde concentration, pH and temperature. Thus the degree of activation is maximal when the enzyme is assayed at approx. 1 mM-acetaldehyde, is greater at 25 degrees C than at 37 degrees C, and is greater at pH 7.4 than at pH 9.75. With low concentrations of acetaldehyde both modifiers decrease the enzyme activity. 2. Diethylstilboestrol affects the sheep liver cytoplasmic enzyme in a very similar way to that previously described for a rabbit liver cytoplasmic enzyme. Preliminary experiments show that the same is true for a preparation of human liver aldehyde dehydrogenase. It is proposed that sensitivity to diethylstilboestrol (and steroids) is a common property of all mammalian cytoplasmic aldehyde dehydrogenases.
摘要
- 本文描述了己烯雌酚和2,2'-二硫代二吡啶对羊肝细胞质醛脱氢酶的激活作用。就乙醛浓度、pH值和温度变化而言，这两种调节剂的作用非常相似。因此，当酶在约1 mM乙醛浓度下进行测定时，激活程度最大；在25℃时比在37℃时更大；在pH 7.4时比在pH 9.75时更大。在低浓度乙醛条件下，两种调节剂都会降低酶活性。2. 己烯雌酚对羊肝细胞质酶的影响与先前描述的兔肝细胞质酶的影响非常相似。初步实验表明，人肝醛脱氢酶制剂也是如此。有人提出，对己烯雌酚（和类固醇）的敏感性是所有哺乳动物细胞质醛脱氢酶的共同特性。
相似文献
1
The activation of aldehyde dehydrogenase by diethylstilboestrol and 2,2'-dithiodipyridine.己烯雌酚和2,2'-二硫代二吡啶对醛脱氢酶的激活作用。
Biochem J. 1982 Oct 1;207(1):81-9. doi: 10.1042/bj2070081.
2
2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.2,2'-二硫代二吡啶激活醛脱氢酶，并保护该酶免受双硫仑的失活作用。
Biochem J. 1979 Dec 1;183(3):751-3. doi: 10.1042/bj1830751.
3
Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.双硫仑和2,2'-二硫代二吡啶对绵羊肝脏细胞质醛脱氢酶的脱氢酶和酯酶活性作用的进一步研究
Biochem J. 1982 Jun 1;203(3):743-54. doi: 10.1042/bj2030743.
4
Effects of diethylstilbestrol, 2,2'-dithiodipyridine, and chloral hydrate on the esterase activity of sheep liver cytoplasmic aldehyde dehydrogenase.己烯雌酚、2,2'-二硫代二吡啶和水合氯醛对绵羊肝脏细胞质醛脱氢酶酯酶活性的影响。
Biochemistry. 1986 Aug 12;25(16):4718-24. doi: 10.1021/bi00364a040.
5
High concentrations of aldehydes slow the reaction of cytoplasmic aldehyde dehydrogenase with thiol-group modifiers.高浓度的醛类物质会减缓细胞质醛脱氢酶与硫醇基团修饰剂的反应。
Biochem J. 1985 Jun 15;228(3):765-7. doi: 10.1042/bj2280765.
6
The time course of the interaction of sheep liver cytoplasmic aldehyde dehydrogenase with 2,2'- and 4,4'-dithiodipyridine: a comparison with the action of disulfiram.
Arch Biochem Biophys. 1984 Nov 1;234(2):487-96. doi: 10.1016/0003-9861(84)90296-0.
7
Reaction between sheep liver mitochondrial aldehyde dehydrogenase and various thiol-modifying reagents.绵羊肝脏线粒体醛脱氢酶与各种硫醇修饰试剂之间的反应。
Biochem J. 1989 Jul 1;261(1):281-4. doi: 10.1042/bj2610281.
8
Activation of aldehyde dehydrogenase by diethylstilbestrol.
Prog Clin Biol Res. 1982;114:37-52.
9
Modification of thiol groups in cytoplasmic aldehyde dehydrogenase.
Alcohol. 1985 Jan-Feb;2(1):97-101. doi: 10.1016/0741-8329(85)90023-0.
10
Partial reversal of the acetaldehyde and butyraldehyde oxidation reactions catalysed by aldehyde dehydrogenases from sheep liver.绵羊肝脏醛脱氢酶催化的乙醛和丁醛氧化反应的部分逆转
Biochem J. 1978 Nov 1;175(2):753-6. doi: 10.1042/bj1750753.
引用本文的文献
1
Probing the active site of cytoplasmic aldehyde dehydrogenase with a chromophoric reporter group.用发色报告基团探测细胞质醛脱氢酶的活性位点。
Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):25-30. doi: 10.1042/bj3000025.
2
Aldehyde dehydrogenase. An enzyme with two distinct catalytic activities at a single type of active site.醛脱氢酶。一种在单一类型活性位点具有两种不同催化活性的酶。
Biochem J. 1985 Aug 15;230(1):261-7. doi: 10.1042/bj2300261.
3
High concentrations of aldehydes slow the reaction of cytoplasmic aldehyde dehydrogenase with thiol-group modifiers.高浓度的醛类物质会减缓细胞质醛脱氢酶与硫醇基团修饰剂的反应。
Biochem J. 1985 Jun 15;228(3):765-7. doi: 10.1042/bj2280765.
本文引用的文献
1
A study of the mechanism by which steroid hormones influence rabbit liver aldehyde dehydrogenase.关于类固醇激素影响兔肝脏醛脱氢酶机制的研究。
J Biol Chem. 1962 May;237:1699-703.
2
Steroid-sensitive aldehyde dehydrogenase from rabbit liver.
J Biol Chem. 1961 Apr;236:1032-7.
3
Studies on ethanol and oral contraceptives: feasibility of a hepatic-gonadal link.乙醇与口服避孕药的研究：肝-性腺联系的可行性
Res Commun Subst Abuse. 1980;1(3):315-33.
4
5
The use of pH-gradient ion-exchange chromatography to separate sheep liver cytoplasmic aldehyde dehydrogenase from mitochondrial enzyme contamination, and observations on the interaction between the pure cytoplasmic enzyme and disulfiram.利用pH梯度离子交换色谱法从线粒体酶污染中分离绵羊肝脏细胞质醛脱氢酶，并对纯细胞质酶与双硫仑之间的相互作用进行观察。
Biochem J. 1981 Dec 1;199(3):573-9. doi: 10.1042/bj1990573.
6
Kinetic mechanism of the human cytoplasmic aldehyde dehydrogenase E1.人细胞质醛脱氢酶E1的动力学机制
Arch Biochem Biophys. 1981 Nov;212(1):9-19. doi: 10.1016/0003-9861(81)90338-6.
7
Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.双硫仑和2,2'-二硫代二吡啶对绵羊肝脏细胞质醛脱氢酶的脱氢酶和酯酶活性作用的进一步研究
Biochem J. 1982 Jun 1;203(3):743-54. doi: 10.1042/bj2030743.
8
Horse liver 3 ,7 ,12 -trihydroxy-5 -cholestan-26-al dehydrogenase as a liver aldehyde dehydrogenase.马肝3,7,12 -三羟基-5 -胆甾烷-26 -醛脱氢酶作为一种肝脏醛脱氢酶。
Biochim Biophys Acta. 1973 Jan 12;293(1):15-25. doi: 10.1016/0005-2744(73)90371-9.
9
Human liver aldehyde dehydrogenase: partial purification and properties.人肝脏醛脱氢酶：部分纯化及性质
Can J Biochem. 1969 Mar;47(3):265-72. doi: 10.1139/o69-041.
10
Isolation and characterization of human liver aldehyde dehydrogenase.
J Biol Chem. 1968 Dec 25;243(24):6402-8.
Zotero 插件