用4,7-菲咯啉-5,6-二酮替代甲氧喋呤，以及其他菲咯啉醌类化合物和7,9-二脱羧甲氧喋呤不能作为醋酸钙不动杆菌中需要甲氧喋呤的葡萄糖脱氢酶的辅因子。
Replacement of methoxatin by 4,7-phenanthroline-5,6-dione and the inability of other phenanthroline quinones, as well as 7,9-di-decarboxy methoxatin, to serve as cofactors for the methoxatin-requiring glucose dehydrogenase of Acinetobacter calcoaceticus.
作者信息
Conlin M, Forrest H S, Bruice T C
出版信息
Biochem Biophys Res Commun. 1985 Sep 16;131(2):564-6. doi: 10.1016/0006-291x(85)91273-2.
PMID:4052066
Abstract
Glucose dehydrogenase from A. calcoaceticus has been dissociated into apoenzyme and methoxatin coenzyme, and enzyme activity restored by replacing coenzyme with 4,7-phenanthroline-5,6-dione but not with 1,10- nor 1,7-phenanthroline-5,6-diones nor with 7,9-decarboxy methoxatin.
摘要
来自醋酸钙不动杆菌的葡萄糖脱氢酶已被解离为脱辅酶和甲氧喋啶辅酶，通过用4,7-菲咯啉-5,6-二酮替代辅酶可恢复酶活性，但用1,10-菲咯啉-5,6-二酮、1,7-菲咯啉-5,6-二酮或7,9-脱羧甲氧喋啶则不能恢复酶活性。
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