Liu Bo, Gong Shide, Chen Yongwei, Xiao Bangming, Wang Junlin, Sun Xinbo
Department of Urology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, Hubei, China.
Am J Cancer Res. 2025 May 15;15(5):2275-2284. doi: 10.62347/DNBH6092. eCollection 2025.
To evaluate the impact of immediate intravesical therapy (IIT) on recurrence rates in non-muscle invasive bladder cancer (NMIBC) patients and to explore the potential protective role of vitamin supplementation.
A retrospective analysis was conducted on 216 NMIBC patients treated between April 2019 and March 2023. Patients were categorized into two groups: IIT group (n = 154) and no-IIT group (n = 62). Inclusion criteria included pathologically confirmed NMIBC, initial transurethral resection of bladder tumor (TURBT), and a minimum follow-up of one year. Patients who underwent radical cystectomy, had other malignancies, or suffered from severe comorbid conditions were excluded. Recurrence within one year post-treatment was used to stratify patients into recurrence and non-recurrence groups. Statistical analyses were performed to identify factors significantly associated with recurrence. Logistic regression and receiver operating characteristic curve analyses were employed to evaluate predictive performance.
The recurrence rate was significantly lower in the IIT group (33.12%) compared to the no-IIT group (95.16%, P < 0.001). IIT significantly reduced the risk of recurrence (P < 0.001). Among vitamin supplements, only vitamin K3 demonstrated a significant association with recurrence (P = 0.010). Logistic regression confirmed IIT as an independent protective factor (OR = 0.026, P < 0.001). The area under the curve (AUC) for individual predictors ranged from 0.587 to 0.754, while the combined model achieved an AUC of 0.877, indicating strong predictive performance.
IIT and self-supplementation with vitamin K3 are associated with a reduced risk of NMIBC recurrence. These findings suggest that adjunctive strategies alongside standard transurethral resection of bladder tumor may enhance patient outcomes. Further prospective studies are warranted to confirm these associations and support their integration into clinical practice.
评估即刻膀胱内灌注治疗（IIT）对非肌层浸润性膀胱癌（NMIBC）患者复发率的影响，并探讨补充维生素的潜在保护作用。
对2019年4月至2023年3月期间接受治疗的216例NMIBC患者进行回顾性分析。患者分为两组：IIT组（n = 154）和非IIT组（n = 62）。纳入标准包括经病理证实的NMIBC、初次经尿道膀胱肿瘤切除术（TURBT）以及至少一年的随访。接受根治性膀胱切除术、患有其他恶性肿瘤或患有严重合并症的患者被排除。治疗后一年内的复发情况用于将患者分为复发组和非复发组。进行统计分析以确定与复发显著相关的因素。采用逻辑回归和受试者工作特征曲线分析来评估预测性能。
IIT组的复发率（33.12%）显著低于非IIT组（95.16%，P < 0.001）。IIT显著降低了复发风险（P < 0.001）。在维生素补充剂中，只有维生素K3与复发有显著关联（P = 0.010）。逻辑回归证实IIT是一个独立的保护因素（OR = 0.026，P < 0.001）。个体预测指标的曲线下面积（AUC）范围为0.587至0.754，而联合模型的AUC为0.877，表明具有较强的预测性能。
IIT和自行补充维生素K3与降低NMIBC复发风险相关。这些发现表明，在标准经尿道膀胱肿瘤切除术的基础上采用辅助策略可能会改善患者的预后。有必要进行进一步的前瞻性研究来证实这些关联，并支持将其纳入临床实践。
