Yao Ming, Zhang Li, Ai Meng, Chen Haiyan, Zhang Lu, Wei Yanshun, Wang Dandan, Jia Yajie
Department of Respiratory Medicine, Wuhan University of Science and Technology Affiliated Geriatric Hospital Wuhan 430000, Hubei, China.
Department of Intensive Care Medicine, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430079, Hubei, China.
Am J Cancer Res. 2025 May 25;15(5):2427-2438. doi: 10.62347/UVQC5990. eCollection 2025.
To evaluate the efficacy and safety of a multidisciplinary team (MDT)-based cardiopulmonary rehabilitation model in patients with intensive care unit-acquired weakness (ICU-AW).
Between January 2020 and June 2023, 80 ICU patients were enrolled: 40 received standard cardiopulmonary rehabilitation (control group), and 40 underwent MDT-based rehabilitation (observation group). Outcome measures included ICU-AW incidence, muscle strength Medical Research Council (MRC) scores, upper/lower limb strength, Barthel Index Sequential Organ Failure Assessment (SOFA) Acute Physiology and Chronic Health Evaluation (APACHE) II scores, duration of ICU and hospital stay, mechanical ventilation time, complications, and patient satisfaction. Predictive variables for ICU-AW were also analyzed.
On days 4 and 7 post-intervention, ICU-AW incidence was significantly lower in the observation group (both P < 0.05). MRC scores, limb muscle strength, Barthel Index, and satisfaction were significantly higher in the observation group (all P < 0.05), while SOFA, APACHE II scores, ICU stay, hospital stay, and ventilation duration were significantly lower (all P < 0.05). SOFA scores declined from day 5, with lower values in the observation group ( < 0.05). The risk of ICU-AW in the observation group was a significant reduction in risk than in the control group (OR = 0.067, 95% CI: 0.005-0.606, P = 0.017). No significant differences in complications were observed (P > 0.05).
MDT-based cardiopulmonary rehabilitation significantly improves muscle strength, functional status, and patient satisfaction, while reducing ICU-AW incidence, ICU and hospital stay, and ventilation duration. These findings support its broader clinical application in ICU-AW management.
评估基于多学科团队（MDT）的心肺康复模式对重症监护病房获得性肌无力（ICU-AW）患者的疗效和安全性。
2020年1月至2023年6月，纳入80例ICU患者：40例接受标准心肺康复（对照组），40例接受基于MDT的康复（观察组）。观察指标包括ICU-AW发生率、肌肉力量医学研究委员会（MRC）评分、上肢/下肢力量、Barthel指数、序贯器官衰竭评估（SOFA）、急性生理与慢性健康状况评估（APACHE）II评分、ICU住院时间和住院时间、机械通气时间、并发症及患者满意度。还分析了ICU-AW的预测变量。
干预后第4天和第7天，观察组ICU-AW发生率显著低于对照组（均P<0.05）。观察组MRC评分、肢体肌肉力量、Barthel指数及满意度均显著高于对照组（均P<0.05），而SOFA、APACHE II评分、ICU住院时间、住院时间及通气时间均显著低于对照组（均P<0.05）。SOFA评分从第5天开始下降，观察组较低（P<0.05）。观察组ICU-AW风险较对照组显著降低（OR=0.067，95%CI：0.005-0.606，P=0.017）。并发症方面未观察到显著差异（P>0.05）。
基于MDT的心肺康复可显著提高肌肉力量、功能状态及患者满意度，同时降低ICU-AW发生率、ICU和住院时间以及通气时间。这些结果支持其在ICU-AW管理中更广泛的临床应用。
