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[高等植物多糖(杂聚糖)的免疫刺激作用]

[Immunostimulating action of polysaccharides (heteroglycans) from higher plants].

作者信息

Wagner H, Proksch A, Riess-Maurer I, Vollmar A, Odenthal S, Stuppner H, Jurcic K, Le Turdu M, Fang J N

出版信息

Arzneimittelforschung. 1985;35(7):1069-75.

PMID:4052142
Abstract

From the water or alcaline-water extracts of Echinacea purpurea (L.) Moench. and -angustifolia DC., Eupatorium cannabium L. and -perfoliatum L., Chamomilla recutita L. Rauscher, Calendula officinalis L., Baptisia tinctoria (L.) R. B., Achyrocline satureioides DC., Arnica montana L., Sabal serrulata Roem. et Schult., and Eleutherococcus (Acanthopanax) senticosus Maxim. polysaccharide fractions with molecular weights in the range of 25 000 to 500 000 and higher have been isolated, which, according to the granulocytes- and carbon clearance tests, showed significant immunostimulating activities. The isolated compounds belong to the group of watersoluble, acidic branched-chain heteroglycans. Their immunostimulating activity is compared and discussed with respect to other polysaccharides of biological activity.

摘要

从紫松果菊(Echinacea purpurea (L.) Moench.)、狭叶松果菊(Echinacea angustifolia DC.)、大麻叶泽兰(Eupatorium cannabium L.)、贯叶泽兰(Eupatorium perfoliatum L.)、德国洋甘菊(Chamomilla recutita L. Rauscher)、金盏花(Calendula officinalis L.)、黄羽扇豆(Baptisia tinctoria (L.) R. B.)、南美鼠尾草(Achyrocline satureioides DC.)、山金车(Arnica montana L.)、锯叶棕(Sabal serrulata Roem. et Schult.)和刺五加(Eleutherococcus (Acanthopanax) senticosus Maxim.)的水提取物或碱性水提取物中,已分离出分子量在25,000至500,000及以上范围内的多糖级分,根据粒细胞和碳清除试验,这些级分显示出显著的免疫刺激活性。分离出的化合物属于水溶性酸性支链杂聚糖类。将它们的免疫刺激活性与其他具有生物活性的多糖进行了比较和讨论。

相似文献

1
[Immunostimulating action of polysaccharides (heteroglycans) from higher plants].[高等植物多糖(杂聚糖)的免疫刺激作用]
Arzneimittelforschung. 1985;35(7):1069-75.
2
[Immunostimulant action of polysaccharides (heteroglycans) from higher plants. Preliminary communication].
Arzneimittelforschung. 1984;34(6):659-61.
3
[Immunologic studies of plant combination preparations. In-vitro and in-vivo studies on the stimulation of phagocytosis].
Arzneimittelforschung. 1991 Oct;41(10):1072-6.
4
[Testing for immunomodulating effects of ethanol-water extracts of the above-ground parts of the plants Echinaceae (Moench) and Rudbeckia L].
Cesk Farm. 1993 Oct;42(5):228-31.
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Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus.刺五加细胞培养物中分离出的多糖通过Toll样受体介导激活B细胞和巨噬细胞。
Int Immunopharmacol. 2003 Sep;3(9):1301-12. doi: 10.1016/S1567-5769(03)00118-8.
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[Advances in the study on chemical constituents and pharmacology of Acanthopanax senticosus (Rupr. et Maxim.)].刺五加(Rupr. 及 Maxim.)化学成分与药理学研究进展
Zhong Yao Cai. 2003 Aug;26(8):603-6.
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Structural features of an immunostimulating and antioxidant acidic polysaccharide from the seeds of Cuscuta chinensis.中国菟丝子种子中一种具有免疫刺激和抗氧化作用的酸性多糖的结构特征
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[Immunomodulating activity of ethanol-water extracts of the roots of Echinacea gloriosa L., Echinacea angustifolia DC. and Rudbeckia speciosa Wenderoth tested on the immune system in C57BL6 inbred mice].[紫松果菊、狭叶松果菊和美丽金光菊根的乙醇 - 水提取物对C57BL6近交系小鼠免疫系统免疫调节活性的研究]
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10
Immunomodulating activity of Echinacea gloriosa L., Echinacea angustifolia DC. and Rudbeckia speciosa Wenderoth ethanol-water extracts.
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