Velican C, Velican D
Atherosclerosis. 1985 Sep;56(3):331-44. doi: 10.1016/0021-9150(85)90008-5.
A light microscopic study on intimal thickening carried out on 932 subjects 1-50 years old and on 22 selected topographic sites of the coronary arterial bed, revealed: (a) In similar topographic sites intimal thickening developed 5-15 years earlier in subjects with than in subjects without minor deviations from the common type of distribution of the coronary arteries. (b) The most rapid development of the intimal layer was detected in children aged 11-15 years. (c) 6% of children who died of acute diseases (mainly acute peritonitis) showed intimal thickening in both major coronary arteries and branch vessels; in children who died of accidents thickening developed only in the major coronary arteries. (d) More than 50% of subjects 46-50 years old (considered to be in the preclinical stage of ischemic heart disease) exhibited intimal thickening in the branch vessels usually non-opened during routine autopsy and non-removed for light-microscopic examination. (e) An intima/media ratio between 2.0 and 3.0 was associated with a 50% reduction in the luminal diameter; this reduction increased up to 75% when the intima/media ratio surpassed 3.0, the very thick intima acquiring the feature of a 'fixed stenotic lesion' in spite of its apparent normal aspect on light-microscopic examination.
对932名年龄在1至50岁之间的受试者以及冠状动脉床的22个选定地形部位进行的内膜增厚的光学显微镜研究显示：(a) 在类似的地形部位，与冠状动脉常见分布类型无微小偏差的受试者相比，有微小偏差的受试者内膜增厚提前5至15年出现。(b) 在内膜层发育最快的是11至15岁的儿童。(c) 死于急性疾病（主要是急性腹膜炎）的儿童中有6%在主要冠状动脉和分支血管中均出现内膜增厚；死于意外事故的儿童仅在主要冠状动脉中出现增厚。(d) 46至50岁的受试者中超过50%（被认为处于缺血性心脏病临床前期）在常规尸检时通常未开放且未取下进行光学显微镜检查的分支血管中出现内膜增厚。(e) 内膜/中膜比值在2.0至3.0之间与管腔直径减少50%相关；当内膜/中膜比值超过3.0时，这种减少增加到75%，尽管在光学显微镜检查中其外观明显正常，但极厚的内膜具有“固定狭窄病变”的特征。
