Pesonen E, Norio R, Hirvonen J, Karkola K, Kuusela V, Laaksonen H, Möttönen M, Nikkari T, Raekallio J, Viikari J
Children's Hospital I, University of Helsinki, Finland.
Eur Heart J. 1990 Aug;11 Suppl E:53-60. doi: 10.1093/eurheartj/11.suppl_e.53.
Narrowings of the coronary arteries were measured in 94 infants aged less than 1 year who died in hospital and 102 1- to 16-year-old children who died accidentally. The arteries were transformed mathematically to circles. The degree of narrowing caused by intimal thickening was determined as the ratio of intimal area to the original luminal area. This ratio was further transformed to percentage. The degree of narrowing varied between 0 and 58% (mean 20%). The mean degree of narrowing in the left coronary artery during the first year of life was 17% and, between 12 and 15 years, 34%. Narrowing was greater in males (P = 0.02), when all the 333 coronary samples were included in the analysis. The birthplaces of the subjects' grandparents were traced from population registers and it was found that narrowing in the left coronary artery of infants was greater in those descended from grandparents from eastern Finland, an area of high mortality from coronary heart disease (CHD). Intimal thickening in infants and children seems to be a morphological manifestation of hereditary predisposition to CHD.
对94名1岁以下死于医院的婴儿以及102名1至16岁意外死亡儿童的冠状动脉狭窄情况进行了测量。将动脉通过数学方法转换为圆形。由内膜增厚导致的狭窄程度被确定为内膜面积与原始管腔面积的比值。该比值进一步转换为百分比。狭窄程度在0%至58%之间（平均20%）。出生后第一年左冠状动脉的平均狭窄程度为17%，12至15岁时为34%。当将所有333个冠状动脉样本纳入分析时，男性的狭窄程度更高（P = 0.02）。通过人口登记册追溯了受试者祖父母的出生地，发现来自芬兰东部（冠心病高死亡率地区）祖父母的婴儿，其左冠状动脉狭窄程度更高。婴幼儿的内膜增厚似乎是冠心病遗传易感性的一种形态学表现。
