Rocque Gabrielle B, Olguin Etzael Ortiz, Shuey Jessi M, Padalkar Tanvi, Williams Courtney P, Azuero Andres, Falcao Ana, Henderson Nicole L, Taub Chloe J, Ream Molly, Yi-Frazier Joyce P, Junkins Courtney C, Reeder-Hayes Katherine, Rosenberg Abby R
Department of Medicine, Division of Hematology Oncology, University of Alabama at Birmingham, 1808 7 Th Avenue S, Birmingham, AL, 35233, USA.
O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Breast Cancer Res Treat. 2025 Jun 16. doi: 10.1007/s10549-025-07741-3.
Women with breast cancer often experience persistent psychological distress. Promoting resilience in stress management (PRISM) is a manualized, skills-based, psychosocial intervention shown to promote resilience and alleviate psychological distress among adolescents and young adults with cancer.
This pilot, convergent mixed methods study examined PRISM's feasibility and in-sample preliminary impact (single-group) on psychosocial outcomes of women with early stage breast cancer (EBC). Women receiving chemotherapy for stage I-III breast cancer completed six standard PRISM sessions focused on rapport building, stress management, goal setting, cognitive reframing, meaning-making, and family integration. Feasibility, the primary outcome, was defined as 70% of participants completing all intervention sessions and pre-post survey. Secondary outcomes included intervention acceptability, appropriateness, and 8 psychosocial outcomes. Patient perspectives on PRISM were elucidated via qualitative interviews and deductively analyze. Pre- and post-intervention changes in survey scores were analyzed using paired t-tests and Cohen's d effect size.
Of 57 patients approached, 30 (53%) participated in PRISM; participants were 57% Black with median age of 51 years (IQR 47-59). PRISM sessions were feasible based on the 83% completion rate. Additional secondary implementation outcomes also demonstrated feasibility, acceptability, and appropriateness using validated survey measured. The largest effects were observed in participants' resilience (d = 0.6), growth (d = 0.5), and self-improvement (d = 0.5). Interviews supported both feasibility and impact of PRISM.
The PRISM-EBC intervention was feasible, and pre-post changes suggest potential benefit, warranting further investigation in a future randomized controlled trial.
乳腺癌女性常经历持续的心理困扰。促进压力管理中的复原力（PRISM）是一种基于技能的手册化心理社会干预措施，已被证明可促进癌症青少年和年轻成人的复原力并减轻心理困扰。
这项试点性的收敛性混合方法研究考察了PRISM对早期乳腺癌（EBC）女性心理社会结局的可行性和样本内初步影响（单组）。接受I-III期乳腺癌化疗的女性完成了六次标准的PRISM课程，这些课程侧重于建立融洽关系、压力管理、目标设定、认知重构、意义建构和家庭融合。可行性作为主要结局，定义为70%的参与者完成所有干预课程和前后调查。次要结局包括干预的可接受性、适宜性以及8项心理社会结局。通过定性访谈阐明患者对PRISM的看法并进行演绎分析。使用配对t检验和科恩d效应量分析干预前后调查分数的变化。
在接触的57名患者中，30名（53%）参与了PRISM；参与者中57%为黑人，中位年龄51岁（四分位间距47-59岁）。基于83%的完成率，PRISM课程是可行的。使用经过验证的调查测量，其他次要实施结局也显示出可行性、可接受性和适宜性。在参与者的复原力（d = 0.6）、成长（d = 0.5）和自我提升（d = 0.5）方面观察到最大的效果。访谈支持了PRISM的可行性和影响。
PRISM-EBC干预是可行的，干预前后的变化表明有潜在益处，值得在未来的随机对照试验中进一步研究。
