Parmar Chintan, Khandelwal Riya, Vasava Mahesh
School of Pharmacy, National Forensic Sciences University, Gandhinagar, Gujarat, India.
J Fluoresc. 2025 Jun 16. doi: 10.1007/s10895-025-04390-z.
Metal-organic frameworks (MOFs) show exceptional potential for the selective detection of hazardous analytes, including explosives, chemical warfare agents, industrial toxins, and other dangerous forensic analytes. Traditional instrumental techniques for trace explosive detection are often costly and inaccessible, creating a need for alternative solutions. MOFs offer a feasible approach through a fluorescence quenching mechanism, leveraging their tunable porosity and extensive surface area to interact specifically with nitroaromatic compounds/explosives., enabling detectable changes in fluorescence. This innovative methodology shows great potential to amplify explosive detection technologies' accessibility and efficiency. However, various challenges remain the same, such as enhancing selectivity, limit of detection, and operational stability of MOFs. This review highlights the recent advancements in MOFs-based detection strategies for nitro compounds and explosives, highlighting their advantages, challenges, limitations, and future scopes without focusing on any specific compound or detection mechanism. By addressing these limitations, MOFs can further strengthen their role in enhancing rapid and reliable detection methods for hazardous analytes.
金属有机框架（MOF）在选择性检测包括爆炸物、化学战剂、工业毒素和其他危险法医分析物在内的有害分析物方面显示出非凡的潜力。传统的痕量爆炸物检测仪器技术往往成本高昂且难以获得，因此需要替代解决方案。MOF通过荧光猝灭机制提供了一种可行的方法，利用其可调孔隙率和大表面积与硝基芳香化合物/爆炸物特异性相互作用，从而实现可检测的荧光变化。这种创新方法在提高爆炸物检测技术的可及性和效率方面显示出巨大潜力。然而，各种挑战依然存在，例如提高MOF的选择性、检测限和操作稳定性。本综述重点介绍了基于MOF的硝基化合物和爆炸物检测策略的最新进展，强调了它们的优点、挑战、局限性和未来发展前景，而不专注于任何特定化合物或检测机制。通过解决这些局限性，MOF可以进一步加强其在增强有害分析物快速可靠检测方法方面的作用。
