Khoshbin Zahra, Davoodian Negin, Taghdisi Seyed Mohammad, Abnous Khalil
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Spectrochim Acta A Mol Biomol Spectrosc. 2022 Aug 5;276:121251. doi: 10.1016/j.saa.2022.121251. Epub 2022 Apr 9.
Advancement in coordination chemistry has achieved an impressive development of metal organic frameworks (MOFs) as the supramolecular hybrid materials, comprising harmonized metal nodes with organic ligands. Scope and approach: MOFs offer the unique properties of easy synthesis, nanoscale structure, adjustable size and morphology, high porosity, large surface area, supreme chemical tunability and stability, and biocompatibility. The features provide an exceptional opportunity for the widely usage of MOFs in the different scientific fields, e.g. biomedicine, electrocatalysis, food safety, energy storage, environmental surveillance, and biosensing platforms. The synergistic incorporation of the aptamer advantages and the superiorities of MOFs attains the novel MOF-based aptasensors. The excellent selectivity and sensitivity of the MOF-based aptasensors nominate them as efficient lab-on-chip tools for cost-effective, label-free, portable, and real-time monitoring of diverse targets.
Here, we review the achievements in the sensor design by cooperation of MOF motifs and aptamers with the conspicuous potential of determining the targets. Finally, some results are expressed that provide a valuable viewpoint for developing the novel MOF-based test strips in the future.
配位化学的进展使金属有机框架（MOF）作为超分子杂化材料取得了令人瞩目的发展，它由金属节点与有机配体协调组成。范围与方法：MOF具有易于合成、纳米级结构、可调节的尺寸和形态、高孔隙率、大表面积、卓越的化学可调性和稳定性以及生物相容性等独特性质。这些特性为MOF在不同科学领域，如生物医学、电催化、食品安全、能量存储、环境监测和生物传感平台等的广泛应用提供了绝佳机会。将适配体的优势与MOF的优势协同结合，可得到新型的基于MOF的适配体传感器。基于MOF的适配体传感器具有出色的选择性和灵敏度，使其成为用于多种目标物的经济高效、无标记、便携式和实时监测的高效芯片实验室工具。
在此，我们综述了通过MOF基序与适配体合作在传感器设计方面取得的成果，这些成果在确定目标物方面具有显著潜力。最后，阐述了一些结果，为未来开发新型基于MOF的测试条提供了有价值的观点。
